Molecular structure of LB-100, CAS Number: 1632032-53-1
LB-100 (CAS 1632032-53-1)
Alternate Names:
(1R,4S)-rel-3-[(4-methyl-1-piperazinyl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid
CAS Number:
1632032-53-1
Molecular Weight:
268.3
Molecular Formula:
C13H20N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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LB-100 (CAS 1632032-53-1) References
- LB-100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. | Fu, QH., et al. 2016. Tumour Biol. 37: 7277-86. PMID: 26666823
- LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation. | Ho, WS., et al. 2018. Cancer Lett. 415: 217-226. PMID: 29199006
- Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma. | Cui, J., et al. 2020. Cancers (Basel). 12: PMID: 31935881
- Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma. | Maggio, D., et al. 2020. J Neurooncol. 148: 231-244. PMID: 32342332
- Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth. | Shuhaibar, LC., et al. 2021. JCI Insight. 6: PMID: 33986191
- Inhibiting PP2A Upregulates B7-H3 Expression and Potentially Increases the Sensitivity of Malignant Meningiomas to Immunotherapy by Proteomics. | Hu, B., et al. 2022. Pathol Oncol Res. 28: 1610572. PMID: 36203966
- An LC-MS/MS method for simultaneous determination of LB-100 and its active metabolite, endothall, in human plasma. | Feng, Y., et al. 2023. Bioanalysis. 15: 1095-1107. PMID: 37584370
- NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis. | Han, WM., et al. 2024. Cell Death Discov. 10: 34. PMID: 38233385
- The phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing. | Dias, MH., et al. 2024. EMBO Rep. 25: 2220-2238. PMID: 38600345
- The PP2A inhibitor LB-100 mitigates lupus nephritis by suppressing tertiary lymphoid structure formation. | Yang, H., et al. 2024. Eur J Pharmacol. 977: 176703. PMID: 38839028
Inhibitor of:
C7orf47, demethylated-PP2A-C, ENPP5, IPP-1, p55 CDC, PP2A-γ, PP2A-Aα, PP2A-Aβ, PP2A-Bα, PP2A-B55-α, PP2A-B55-β, PP2A-B55-δ, PP2A-B55-γ, PP2A-B56-α, PP2A-B56-β, PP2A-B56-δ, PP2A-B56-γ, PP2A-B72/B130, PP2A-Cα, PP2A-Cβ, PP6, PPP2R3A, PPP2R3C, PPP2R5E, PPP4R4, and PTP beta.Activator of:
PP1α, PP2A-γ, PP2A-Bα, PP2A-B55-β, Ppp2r3d, and Tip41.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LB-100, 10 mg | sc-507368 | 10 mg | $330.00 |