Endothall: sc-201325. Immunofluorescence staining of methanol-fixed lambda protein phosphatase (sc-200312A) treated (A,B) and Endothall treated (B) NIH/3T3 cells showing nuclear localization and chemical inactivation of lambda phosphatase. Antibody tested: p-NFκB p50 (A-8): sc-271908.
Endothall (CAS 145-73-3)
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Alternate Names:
Aquathol
Application:
Endothall is an herbicidal inhibitor of PP2A phosphatase activity
CAS Number:
145-73-3
Purity:
≥98%
Molecular Weight:
186.16
Molecular Formula:
C8H10O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Endothall is a small molecule inhibitor of PP2A (protein phosphatase), used as a defoliant and a known toxin to animals. Endothall shows intermediate inhibition of PP2A (IC50=970 nM), displaying near 50% inhibition of phosphatase activity. The 2,3-dimethyl analogs of Endothall, such as Cantharidin (2,3-dimethyl anhydride analog, sc-201321), approach full inhibition of the phosphatase.
Endothall (CAS 145-73-3) References
- Effects and persistence of endothall in the aquatic environment. | Holmberg, DJ. and Lee, GF. 1976. J Water Pollut Control Fed. 48: 2738-46. PMID: 1003675
- Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. | Thièry, JP., et al. 1999. Hepatology. 29: 1406-17. PMID: 10216123
- On the cardiac contractile, electrophysiological and biochemical effects of endothall, a protein phosphatase inhibitor. | Bokník, P., et al. 2000. Pharmacology. 61: 43-50. PMID: 10895080
- Multiple cyclin-dependent kinase complexes and phosphatases control G2/M progression in alfalfa cells. | Mészáros, T., et al. 2000. Plant Mol Biol. 43: 595-605. PMID: 11089863
- Uptake, distribution, and metabolism of endothall in fish. | Sikka, HC., et al. 1975. J Agric Food Chem. 23: 849-51. PMID: 1159181
- Cantharidin-binding protein: identification as protein phosphatase 2A. | Li, YM. and Casida, JE. 1992. Proc Natl Acad Sci U S A. 89: 11867-70. PMID: 1334551
- Latent Toxicity of Endothall to Anadromous Salmonids During Seawater Challenge. | Courter, LA., et al. 2016. Bull Environ Contam Toxicol. 96: 573-9. PMID: 27000379
- Sediment Facilitates Microbial Degradation of the Herbicides Endothall Monoamine Salt and Endothall Dipotassium Salt in an Aquatic Environment. | Islam, MS., et al. 2018. Int J Environ Res Public Health. 15: PMID: 30326645
- Endothall behavior in Myriophyllum spicatum and Hydrilla verticillata. | Ortiz, MF., et al. 2019. Pest Manag Sci. 75: 2942-2947. PMID: 30854787
- Compartmentalization and persistence of endothall in experimental pools. | Reinert, KH., et al. 1985. Ecotoxicol Environ Saf. 10: 86-96. PMID: 4029061
- Persistence of endothall in aquatic environment as determined by gas-liquid chromatography. | Sikka, HC. and Rice, CP. 1973. J Agric Food Chem. 21: 842-6. PMID: 4733376
- Toxicity of the herbicides endothall and diquat to benthic crustacea. | Williams, EH., et al. 1984. Bull Environ Contam Toxicol. 33: 418-22. PMID: 6487836
- Influence of sediment types on the sorption of endothall. | Reinert, KH. and Rodgers, JH. 1984. Bull Environ Contam Toxicol. 32: 557-64. PMID: 6733302
- Endothall thioanhydride inhibits protein phosphatases-1 and -2A in vivo. | Erdödi, F., et al. 1995. Am J Physiol. 269: C1176-84. PMID: 7491907
- Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues. | Li, YM., et al. 1993. Biochem Pharmacol. 46: 1435-43. PMID: 8240393
Inhibitor of:
4921523A10Rik, 4932429P05Rik, ARMCX1, ARPP-21, CCDC25, Cdc14b Phosphatase, DUSP20, FAM62C, FAPP2, FASP1, FEM-2, Gm70, I1PP2A, I2PP2A, KIAA0408, KIAA1219, LCMT1, LPPR3, LRRC68, MDP-1, MIPP, OCRL, Okadaic Acid, OS4, OST-PTP, p55 CDC, Pcdhb17, PHI-1, PHLPPL, phosphatasefamily surface anchored protein, PME-1, PP1α, PP2, PP2A-β, PP2A-δ, PP2A-γ, PP2A-Bα, PP2A-B55-α, PP2A-B55-β, PP2A-B55-δ, PP2A-B55-γ, PP2A-B56-β, PP2A-B56-δ, PP2A-B56-γ, PP2A-B72/B130, PP2B-Aβ, PP2C, PP2Cε, PP6, PP6R3, PPEF-1, PPM1H, PPP1R12C, PPP1R14D, PPP1R3, PPP1R3E, PPP1R3F, PPP1R3G, PPP1R4, PPP2R3A, PPP2R3C, Ppp4r1l, PPP4R4, PR48, PTP-H1, PTPρ, PTPLAD2, SCRN3, Sds22, TMEM170, TMEM24, Type I 4-phoshatase α, Type I 4-phoshatase β, Type II 4-phoshatase, and Type II 4-phoshatase β.Activator of:
2010007H12Rik, 4921523A10Rik, ANKRD52, B430203M17Rik, Cdc14a phosphatase, Cdc14b Phosphatase, DUSP22, Gm1568, Gm1574, Gm70, LHPP, LRRC67, MCC, Neurabin-I, PDPc, phostensin, PP1γ, PP2A-β, PP2A-δ, PP2A-γ, PP2A-Aα, PP2A-Bα, PP2A-B55-β, PP2A-B56-α, PP2A-B56-γ, PP2Cα, PP2Cζ, PP5, PP6R3, PPM1H, PPP1R1C, PPP2R3C, Ppp2r3d, PPP4R4, RPL24, RPL39, Rshl2a, Rslcan-1, SAA2, SSH3, and Tctex5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Endothall, 20 mg | sc-201325 | 20 mg | $48.00 | |||
Endothall, 100 mg | sc-201325A | 100 mg | $199.00 |