Molecular structure of Cantharidin, CAS Number: 56-25-7
Cantharidin (CAS 56-25-7)
See product citations (6)
Alternate Names:
Cantharone; Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
Application:
Cantharidin is a toxic herbicidal potent inhibitor of PP2A phosphatase activity
CAS Number:
56-25-7
Purity:
≥98%
Molecular Weight:
196.20
Molecular Formula:
C10H12O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cantharidin is a natural compound found in the beetle species of the Meloidae family. It is a potent small molecule inhibitor of PP2A (protein phosphatase 2A) used as an herbicide. Cantharidin shows strong inhibition of PP2A (IC50=40 nM) compared to the analog Endothall (sc-201325), with Cantharidin displaying near complete inhibition of phosphatase activity.
Cantharidin (CAS 56-25-7) References
- Cantharidin-binding protein: identification as protein phosphatase 2A. | Li, YM. and Casida, JE. 1992. Proc Natl Acad Sci U S A. 89: 11867-70. PMID: 1334551
- The effects of cantharidin and cantharidin derivates on tumour cells. | Liu, D. and Chen, Z. 2009. Anticancer Agents Med Chem. 9: 392-6. PMID: 19442040
- Cantharidin toxicosis in horses. | Schmitz, DG. 1989. J Vet Intern Med. 3: 208-15. PMID: 2685272
- Cantharidin inhibits competitively heme-Fe(III) binding to the FA1 site of human serum albumin. | Polticelli, F., et al. 2017. J Mol Recognit. 30: PMID: 28608578
- Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway. | Gu, XD., et al. 2017. Braz J Med Biol Res. 50: e5920. PMID: 28678918
- Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives. | Ren, Y. and Kinghorn, AD. 2021. Bioorg Med Chem. 32: 116012. PMID: 33454654
- Cantharidin-Induced Skin Blister as an In Vivo Model of Inflammation. | Dawson, J. and Vogelsanger, M. 2021. Curr Protoc. 1: e49. PMID: 33600079
- ABC transporter Pdr5 is required for cantharidin resistance in Saccharomyces cerevisiae. | Swagatika, S. and Tomar, RS. 2021. Biochem Biophys Res Commun. 553: 141-147. PMID: 33770579
- Cantharidin downregulates PSD1 expression and inhibits autophagic flux in yeast cells. | Swagatika, S. and Tomar, RS. 2022. FEBS Open Bio. 12: 1017-1035. PMID: 33999504
- Hepatotoxicity of cantharidin is associated with the altered bile acid metabolism. | Cheng, W., et al. 2022. J Appl Toxicol. 42: 970-980. PMID: 34866203
- Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis-Inducing Genes S100A4 and MACC1. | Schöpe, PC., et al. 2023. Int J Mol Sci. 24: PMID: 36674695
- Cantharidin induces senescence via inhibition of AMP-activated protein kinase and activation of NLRP3 inflammasome in H9c2 cardiomyocytes. | Shi, Y., et al. 2022. Pak J Pharm Sci. 35: 1827-1834. PMID: 36861250
- Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues. | Li, YM., et al. 1993. Biochem Pharmacol. 46: 1435-43. PMID: 8240393
Inhibitor of:
1700019N19Rik, 4921523A10Rik, 4932429P05Rik, ALP, ARPP-21, B430203M17Rik, BRF2, C7orf47, CCDC25, Cdc14b Phosphatase, CPPED1, CTDSPL, CYB561D1, demethylated-PP2A-C, DUSP20, FAM171A1, FASP1, FEM-2, Gm70, GS1, I1PP2A, I2PP2A, IAP, Ime1, IPP-1, Khdc1c, KIAA0408, LCMT1, LPPR3, LRRC68, MDP-1, MIPP, MPPE1, MPPED1, MYPT3, Na+/K+-ATPase α1, Na+/K+-ATPase α3, NIPP1, NOSTRIN, Okadaic Acid, OS4, OST-PTP, p55 CDC, PAP-2c, patched, PHACTR1, PHACTR3, PHI-1, PHLPPL, phosphatasefamily surface anchored protein, PME-1, Pol II-H, Polr2j, POLR2L, PP1α, PP1β, PP1γ, PP2, PP2A-β, PP2A-δ, PP2A-γ, PP2A-Aα, PP2A-Aβ, PP2A-Bα, PP2A-B55-α, PP2A-B55-β, PP2A-B55-δ, PP2A-B55-γ, PP2A-B56-α, PP2A-B56-β, PP2A-B56-δ, PP2A-B56-γ, PP2A-B72/B130, PP2A-Cα, PP2A-Cβ, PP2B-Aβ, PP2C, PP2Cε, PP4R1, PP6, PP6R3, PPEF-1, PPEF-2, PPM1H, PPM1N, PPP1R12C, PPP1R14D, PPP1R3, Ppp1r3d, PPP1R3E, PPP1R3F, PPP1R3G, PPP1R4, PPP1R6, PPP2R3A, PPP2R3C, PPP2R4, PPP2R5E, Ppp4r1l, PPP4R4, PR48, PRIP, PTP-H1, PTPδ, PTPρ, PTPLAD2, RSP3, Sds22, SE, SH-PTP1, STEP, TAF I p110_TAF I p95, Type I 4-phoshatase α, Type I 4-phoshatase β, Type II 4-phoshatase, Type II 4-phoshatase β, VHX, ZFP54, ZFP60, ZFP677, ZFP692, Zfp735, ZNF364, ZNHIT4, and ZSCAN12.Activator of:
1700057K13Rik, 1810063B07Rik, 2010007H12Rik, 2810403A07Rik, 4632434I11Rik, 4921523A10Rik, 4930527E24Rik, 4930534B04Rik, 4930538K18Rik, 4933402P03Rik, 4933432B09Rik, A630018P17Rik, Adenovirus-1 hexon E11, AI464131, ANKRD52, ANKRD61, ANP32C, B430203M17Rik, C17orf66, CCDC158, CD45RC, Cdc14a phosphatase, Cdc14b Phosphatase, Centaurin β5, CXorf26, D-type cyclin, DUSP22, DUSP26, DUSP28, DUXA, FAM40B, FKBP12.6, GAGE8, GFR-1, GLEPP1, Gm2897, Gm70, Gm8994, Gm9766, GOLGA6L1, KIAA1751, KRTAP5-10, KRTAP5-7, KRTAP5-9, LCTL, LHPP, LOC100041253, LOC100129240, LRRC14B, LRRC30, LRRC67, MCC, MDP-1, Neurabin-I, OSR1, OTTMUSG00000015050, OTTMUSG00000015173, OTTMUSG00000015220, OTTMUSG00000015279, OTTMUSG00000015337, OTTMUSG00000015417, PDPc, phostensin, Pin1l, PKDCC, POLR2L, POLR3H, PP2A-β, PP2A-δ, PP2A-γ, PP2A-Bα, PP2Cα, PP2Cζ, PP5, PP6R3, PPM1H, PPP1R1C, PPP2R3C, Ppp2r3d, PPP4R4, PRB4, Profilin-4, Psg16, Psmg2, PTP22, PTPRCAP, PTPy, PTTG2, Pyhin1, Ran BP-17, RBMY1A, Ribosomal Protein L7A, RPL24, RPL39, RPTPα, Rshl2a, Rslcan-1, SAA2, SerpinA3m, SF3B10, SFRS12IP1, SFT2D3, SH3BGRL2, Skint11, SMEK1, SNED1, SPANX-A2, SPANX-FI, SPINK1, SPINK12, SPINK13, SSH3, stefin A2l1, Tctex5, TFIIA-β, TFIIF RAP 30, TFIIIC35, ThrRS, Tip41, Trav12d-1, U2AF1L3, UBLCP1, UEV3, VHR, ZBTB44, ZFP719, ZFP760, ZFP810, ZFP819, ZFP97, ZFY2, ZNF440, ZNF559, and ZNF565.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cantharidin, 25 mg | sc-201321 | 25 mg | $81.00 | |||
Cantharidin, 100 mg | sc-201321A | 100 mg | $260.00 |