podoplanin Activators
Common podoplanin Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Dexamethasone CAS 50-02-2, PMA CAS 16561-29-8, PGE2 CAS 363-24-6 and Lysophosphatidic Acid CAS 325465-93-8.
Podoplanin activators are compounds that stimulate the activity or expression of podoplanin, a type-I transmembrane sialomucin-like glycoprotein. Widely expressed across various tissues, podoplanin has been identified in a number of cell types, including lymphatic endothelial cells, kidney podocytes, and certain types of cancer cells. The protein is characterized by its unique O-glycosylation pattern, which influences its interaction with other cellular and extracellular components.
One of the most recognized roles of podoplanin is its involvement in the development and maintenance of the lymphatic system. In lymphatic endothelial cells, podoplanin plays a crucial role in maintaining cell shape, promoting cell-cell interactions, and ensuring the proper formation of lymphatic vessels. The protein accomplishes these functions, in part, by binding to C-type lectin-like receptor 2 (CLEC-2) on platelets, an interaction that is essential for separating the lymphatic system from the blood vasculature during embryonic development. Beyond its roles in lymphangiogenesis, podoplanin has been implicated in various cellular processes, including cell migration, adhesion, and proliferation. Podoplanin activators, by enhancing the protein's activity or expression, can influence these cellular dynamics, impacting tissue development, regeneration, and homeostasis. Understanding the mechanisms and implications of podoplanin activation offers profound insights into the protein's multifaceted roles across different biological contexts. Exploring the realm of podoplanin activators emphasizes the significance of this glycoprotein in orchestrating intricate cellular behaviors, underlining its importance in tissue morphogenesis and maintenance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Influences cell differentiation and growth. It might modulate podoplanin expression in certain cell types. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A synthetic glucocorticoid that can modulate inflammation and immune responses. May influence podoplanin expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PKC activator that can induce cellular changes leading to podoplanin expression in some cell types. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Known to induce podoplanin expression in some endothelial cells via activation of protease-activated receptors. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Influences a variety of physiological processes and can induce podoplanin in certain cellular contexts. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
G-protein-coupled receptor activator known to induce podoplanin in some cell types. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural compound that can influence a variety of cellular processes. It may modulate podoplanin expression in some contexts. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Flavonoid with anti-inflammatory properties that might modulate podoplanin expression in certain settings. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Natural compound with potential anti-cancer properties. It might influence podoplanin expression in certain cell types. | ||||||
Salidroside | 10338-51-9 | sc-472942 | 50 mg | $360.00 | 1 | |
A compound known for its anti-inflammatory effects which might influence podoplanin expression. | ||||||