PNPO Activators
PNPO activators refers to a category of compounds or molecules that have the capability to modulate the activity or expression of the Pyridoxamine 5'-Phosphate Oxidase (PNPO) enzyme. PNPO is an essential enzyme involved in the metabolism of vitamin B6 (pyridoxine). Its primary function is to convert pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), which are biologically inactive forms of vitamin B6, into the active form, pyridoxal 5'-phosphate (PLP). PLP serves as a cofactor for a variety of enzymes involved in numerous biochemical processes, including amino acid metabolism, neurotransmitter synthesis, and heme biosynthesis.
PNPO activators, therefore, play a crucial role in regulating the conversion of inactive vitamin B6 forms into the active PLP form. This activation process is essential for maintaining cellular functions and ensuring that the body has an adequate supply of active vitamin B6. By modulating PNPO activity, these activators can indirectly influence the availability of PLP, which, in turn, affects various enzymatic reactions crucial for overall health and homeostasis. Understanding PNPO activators and their impact on vitamin B6 metabolism is vital for advancing our knowledge of the role of this essential vitamin in maintaining proper cellular function and metabolic processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can regulate gene expression through nuclear receptors, potentially affecting PNPO expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor may lead to demethylation of the PNPO gene promoter, potentially upregulating its expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, it may increase histone acetylation and potentially upregulate PNPO expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can increase cAMP levels, potentially activating transcription factors that regulate PNPO. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
This HDAC inhibitor can cause chromatin remodeling, potentially leading to increased expression of PNPO. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can modulate signaling pathways and epigenetic marks, potentially influencing PNPO expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can affect gene expression through its interaction with various signaling pathways, possibly influencing PNPO. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to have epigenetic modulatory effects, which could potentially upregulate PNPO expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane has been shown to have HDAC inhibitory activity, which might enhance PNPO expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can affect GSK-3 activity and Wnt signaling, which might influence PNPO expression. | ||||||