PKC λ/ι Activators
Protein Kinase C lambda/iota (PKC λ/ι) activators belong to a unique category of compounds that specifically interact with and modulate the activity of the PKC λ/ι isoforms, which are members of the atypical protein kinase C subfamily. Unlike the conventional PKCs that are activated by calcium and diacylglycerol, and the novel PKCs that are activated by diacylglycerol but not calcium, the atypical PKCs (including PKC λ/ι) are insensitive to both calcium and diacylglycerol. Instead, they are activated by other lipids such as phosphatidic acid and phosphoinositides, and their activity is regulated by protein-protein interactions and phosphorylation events. The atypical PKCs play crucial roles in a variety of cellular processes including cell survival, proliferation, differentiation, and migration.
PKC λ/ι activators interact with the enzyme in a way that enhances its kinase activity, often by stabilizing the active conformation of the enzyme or by facilitating its interaction with requisite co-factors or substrates. These activators can be small organic molecules, peptides, or other types of chemical entities. Their interaction with PKC λ/ι is highly specific, and they do not significantly affect the activity of other PKC isoforms or unrelated kinases. The structural basis for this specificity is rooted in the unique features of the PKC λ/ι catalytic and regulatory domains, which confer a distinct binding pocket and activation mechanism for these isoforms. The study and characterization of PKC λ/ι activators have provided valuable insights into the molecular details of PKC λ/ι regulation and function, contributing to our understanding of the complex signaling networks in which these kinases participate.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound found in turmeric, has been shown to influence various signaling pathways, potentially leading to the upregulation of PKC λ/ι expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural polyphenol found in grapes and berries. It may modulate PKC λ/ι activity indirectly by influencing oxidative stress and inflammation-related pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties. It has been shown to interact with various signaling molecules, possibly leading to changes in PKC λ/ι expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, a compound found in cruciferous vegetables, is known for its ability to induce detoxifying enzymes. It may also affect PKC λ/ι expression through its influence on oxidative stress and inflammation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, plays a crucial role in cell growth and differentiation. It has been shown to modulate the expression of various proteins, potentially including PKC λ/ι. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is the most abundant catechin in green tea. It is known for its antioxidant properties and may influence PKC λ/ι expression through various signaling pathways. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D, particularly in its active form, plays a significant role in calcium homeostasis and bone metabolism. It may also influence the expression of PKC λ/ι indirectly through its regulatory effects on various cellular processes. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide is a reactive oxygen species that plays roles in cell signaling and homeostasis. It may modulate PKC λ/ι expression through oxidative stress-mediated signaling pathways. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is a metal known to affect various signaling pathways and cellular processes. It may influence PKC λ/ι expression indirectly through its impacts on neurotransmitter release and cellular signaling. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is a well-known stimulant found in coffee and other beverages. It may modulate PKC λ/ι expression through its effects on cyclic AMP levels and signaling pathways related to cellular stress and metabolism. | ||||||