PIG-H Activators
PIG-H Activators function through a variety of signaling pathways to increase the activity of this crucial enzyme in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. Certain activators work by enhancing intracellular cAMP levels, which then activate protein kinase A (PKA), a kinase that is known to influence GPI anchor synthesis. This is achieved either through the direct activation of adenylate cyclase or by mimicking cAMP itself, thus providing a boost to the PKA signaling cascade that can favor the activity of PIG-H. Other activators interact with membrane receptors and cellular signaling molecules to increase intracellular calcium concentrations. This rise in calcium ions can activate calcium-dependent protein kinases that may subsequently enhance the functional activity of PIG-H, ensuring the efficient production of GPI anchors needed for cell surface protein attachment.
Additional activators indirectly support the function of PIG-H by targeting various other enzymes and pathways that intersect with GPI anchor biosynthesis. Some compounds inhibit key kinases or phosphatases, leading to altered phosphorylation states of proteins that could modulate the biosynthetic pathway of GPI anchors, thereby impacting PIG-H activity. Others interfere with metabolic pathways such as sphingolipid metabolism, or signal transduction pathways like the Wnt signaling, affecting the lipid composition and the cellular microenvironment in which PIG-H operates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels, which may enhance PIG-H activity through cAMP-dependent protein kinase (PKA) signaling, known to influence glycosylphosphatidylinositol (GPI) anchor biosynthesis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC) which can lead to enhanced PIG-H activity by modulating the phosphatidic acid levels in membranes, a component necessary for GPI anchor synthesis. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium concentration, which could activate calcium-dependent protein kinases influencing PIG-H activity and GPI anchor synthesis. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Functions as a calcium ionophore, raising intracellular calcium levels and potentially enhancing PIG-H function through calcium-dependent signaling pathways involved in GPI anchor assembly. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that activates PKA, potentially increasing PIG-H activity by influencing GPI anchor biosynthesis via the cAMP/PKA signaling pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that increases cAMP levels, potentially enhancing PIG-H activity by PKA-dependent regulation of GPI anchor biosynthesis. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits glycogen synthase kinase-3 (GSK-3), which might indirectly increase PIG-H activity by influencing Wnt signaling pathway components that are known to be modified by GPI anchors. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
Inhibits Ras farnesyltransferase, which could indirectly increase PIG-H activity by altering the prenylation status of proteins, potentially impacting pathways that regulate GPI anchor synthesis. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Inhibits protein phosphatases PP1 and PP2A, which could lead to the activation of downstream kinases, indirectly increasing PIG-H activity by modulating the phosphorylation state of proteins involved in GPI anchor biosynthesis. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Inhibits protein tyrosine kinases, potentially enhancing PIG-H activity through altered signaling pathways that are dependent on tyrosine phosphorylation, which may impact GPI anchor synthesis. | ||||||