PIG-H Inhibitors
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Inhibits the enzyme farnesyltransferase, which is crucial for the post-translational modification of proteins associated with cell signaling. PIG-H is dependent on proper protein lipidation for its function; thus, inhibition of farnesyltransferase can indirectly affect PIG-H activity. | ||||||
Triton X-100 | 9002-93-1 | sc-29112 sc-29112A | 100 ml 500 ml | $20.00 $42.00 | 55 | |
A nonionic surfactant that disrupts lipid rafts in cellular membranes. Since PIG-H is involved in glycolipid anchoring within the membrane, disruption of lipid rafts can impair PIG-H-mediated anchoring processes. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
An inhibitor of ADP-ribosylation factor (Arf) proteins, disturbs Golgi apparatus structure and function. As PIG-H is involved in biosynthetic processes that localize to the Golgi, this compound's action can indirectly impact PIG-H's function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
A carboxylic ionophore that alters intracellular pH and ion gradients, affecting Golgi function. By disrupting the Golgi where PIG-H operates, this compound can indirectly inhibit PIG-H's biosynthetic activity. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
An inhibitor of fatty acid synthase, it hinders the synthesis of fatty acids necessary for lipid biosynthesis. As PIG-H relies on lipid modifications for its function, this compound's inhibition of fatty acid production can indirectly affect PIG-H activity. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $184.00 $632.00 | 10 | |
An inhibitor of glucosidases that impedes N-linked glycosylation, a process often preceding PIG-H mediated modifications. This can indirectly inhibit PIG-H by disrupting the glycosylation necessary for its function. | ||||||
Mevastatin (Compactin) | 73573-88-3 | sc-200853 sc-200853A | 10 mg 50 mg | $77.00 $179.00 | 18 | |
An HMG-CoA reductase inhibitor, it blocks cholesterol biosynthesis, which can alter membrane composition and fluidity, potentially affecting PIG-H's anchoring capacity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
An inhibitor of N-linked glycosylation, it can disrupt the glycosylation of proteins that interact with PIG-H, indirectly affecting PIG-H's role in glycan anchor biosynthesis. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $118.00 $148.00 | 26 | |
A polyene macrolide that binds to cholesterol, disrupting lipid raft formation within cell membranes where PIG-H-related activities take place, potentially inhibiting PIG-H's function. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
A β-adrenergic receptor antagonist that also disrupts clathrin-mediated endocytosis, a pathway that might intersect with PIG-H's role in cell membrane dynamics, thereby indirectly inhibiting PIG-H. | ||||||