Manumycin A CAS: 52665-74-4
MF: C31H38N2O7
MW: 550.7
An antibiotic that acts as a selective and vigorous inhibitor of Ras farnesyltransferase.

Manumycin A (CAS 52665-74-4)

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Application An antibiotic that acts as a selective and vigorous inhibitor of Ras farnesyltransferase
CAS 등록번호: 52665-74-4
순도: ≥96%
분자량: 550.7
분자식: C31H38N2O7
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Manumycin A is an antibiotic originally generated by Streptomyces parvulus that acts as a selective and vigorous inhibitor of Ras farnesyltransferase. The compound has been observed to block the activity of IKKβ by robustly and rapidly inhibiting TNF alpha induced phosphorylation of IκBα and NF-κB nuclear translocation. Studies indicate that Manumycin A has the ability to induce the dimerization of IKKβ and dissociation of IKK from IKKγ/NEMO, the adapter protein. Atherosclerosis studies report that Manumycin A decreases oxidative stress. Additionally, Manumycin A irreversibly inhibits neutral sphingomyelina, and has been shown to produce nitric oxide and induce apoptosis in leukemia cell studies. Manumycin A is an inhibitor of Farnesyl Transferase and N-SMase.


References

1. Hara, M., et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 2281-2285. PMID: 8460134
2. Zou, Y., et al. 1996. J. Biol. Chem. 271: 33592-33597. PMID: 8969227
3. Arenz, C., et al. 2001. Chembiochem. 2: 141-143. PMID: 11828438
4. She, M., et al. 2005. Leukemia. 19: 595-602. PMID: 15744347
5. Bernier, M., et al. 2006. J. Biol. Chem. 281: 2551-2561. PMID: 16319058
6. Sugita, M., et al. 2007. Arterioscler. Thromb. Vasc. Biol. 27: 1390-1395. PMID: 17363690

Physical State :
Solid
용해도 :
Soluble in ethanol (5 mg/ml), DMSO (10 mg/ml), DMF (20 mg/ml), 1:1 DMF:PBS (pH 7.2) (0.5 mg/ml), CHCl3, and MeOH. Insoluble in water.
저장 :
Store at -20° C
비등점 :
~863.6° C at 760 mmHg (Predicted)
밀도 :
~1.3 g/cm3 (Predicted)
굴절률 :
n20D 1.60
IC50 :
GGTase I: IC50 = 180 µM; FTase: IC50 = 5 µM
Ki 데이타 :
FPP: Ki= 1.2 µM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
6438330
MDL Number :
MFCD00920782
SMILES :
CCCC[[email protected]@H](C)/C=C(\\C)/C=C(\\C)/C(=O)NC1=C[[email protected]]([[email protected]]2[[email protected]@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O

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Manumycin A  논문정보

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Citations 1 to 3 of {3} total

PMID: # 11044431  Marra, DE. et al. 2000. Circulation. 102: 2124-2130.

PMID: # 8460134  Hara, M. et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 2281-2285.

PMID: # 28036370  PLoS Pathog. 12: e1006139.

Citations 1 to 3 of {3} total
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