Brefeldin A CAS: 20350-15-6
MF: C16H24O4
MW: 280.36
A fungal metabolite exhibiting a wide range of antibiotic activities and activator of caspase-3.

Brefeldin A (CAS 20350-15-6)

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Synonym: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin
Application A fungal metabolite exhibiting a wide range of antibiotic activities and activator of caspase-3
CAS 등록번호: 20350-15-6
순도: ≥98%
분자량: 280.36
분자식: C16H24O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Brefeldin A is a fungal metabolite that disrupts the structure and function of the Golgi apparatus. The compound induces the Golgi proteins to redistribute into the ER and blocks the secretion from the Golgi apparatus. Studies show that it blocks the GTP-dependent interaction of ARF with the Golgi membrane, thus inhibiting the assembly of coatomer onto the membrane. Research shows that Brefeldin A can induce apoptosis in Neuroendocrine tumor cells by activating caspase-3, and inhibits cell growth by targeting the cell cycle in prostate cancer cells. Brefeldin A is an inhibitor of ARF.


References

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Physical State :
Solid
에서 유래된 :
Eupenicillum sp. UN88
용해도 :
Soluble in water (Partly miscible), methanol (10 mg/mL), ethanol (5 mg/mL), DMSO (20 mg/mL), acetone, and ethyl acetate (1 mg/mL).
저장 :
Store at -20° C
녹는점 :
200° C
비등점 :
~492.7° C at 760 mmHg (Predicted)
밀도 :
~1.1 g/cm3 (Predicted)
굴절률 :
n20D 1.51
Optical Activity :
α20/D 96°±2° in methanol; α20/D 93°, c = 2 in methanol
IC50 :
B-cell specific antigen receptor-induced NF-kB activation: IC50 = 420 nM (HEK-293T cell line)
pK Values :
pKa: 12.92
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
GY8410000
PubChem CID :
5287620
Merck Index :
14: 1369
MDL Number :
MFCD00083258
EC Number :
247-104-4
Beilstein Registry :
25191

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Brefeldin A  논문정보

다른 사용자의 Brefeldin A사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 10 of {3} total

PMID: # 29295953  Shim, SM. et al. 2018. Sci Signal. 11:

PMID: # 27818291  Wanka, L. et al. 2017. Cell. Signal. 29: 233-239.

PMID: # 27121042  Schumacher, MM. et al. 2016. J. Lipid Res. 57: 1286-99.

PMID: # 24943726  Vogelzang, A. et al. 2014. J. Infect. Dis. 210: 1928-37.

PMID: # 25319670  Chang, FY. et al. 2014. Biochemistry. 53: 7123-31.

PMID: # 22998223  Luo, Y. et al. 2013. Traffic. 14: 97-106.

PMID: # 22767227  Cai, Q. et al. 2012. FASEB J. 26: 3306-20.

PMID: # 22275357  Tachikawa, M. et al. 2012. The Journal of biological chemistry. 287: 8398-406.

PMID: # 16467202  Zernecke A, et al. 2006. Blood. 107(11): 4240-4243.

PMID: # 26942056  Gao, J.|Duan, Z.|Zhang, L.|Huang, X.|Long, L.|Tu, J.|Liang, H.|Zhang, Y.|Shen, T.|Lu, F.| et al. Oncoimmunology. 5: e1048061.

Citations 1 to 10 of {3} total
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