Tunicamycin CAS: 11089-65-9
MF: C38H62N4O16 (Tun B)
MW: 840.0 (Avg.)

Tunicamycin (CAS 11089-65-9)

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Tunicamycin is rated 4.5 out of 5 by 2.
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Alternate Names: Tunicamycin also known as nucleoside antibiotic
Application Tunicamycin is a competitive cell cycle inhibitor exhibiting antiungal properties and is widely used in the study of glycoprotein synthesis
CAS 등록번호: 11089-65-9
순도: ≥99% (total complex)
분자량: 840.0 (Avg.)
분자식: C38H62N4O16 (Tun B)
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
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* 참조분석증명서대량의 측정 데이터(함수량포함).

Tunicamycin is a mixture of tunicamycins A, B, C and D and has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GlcNAc phosphotransferase (GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein sunthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, inhibit protein glycosylation, suppression of the S phase and to also arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, tunicamycin is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Through this mechanism, it has been postulated to arrest cell cycling as a competitive inhibitor of glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins which thereby affect the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.


References

1. Duksin, D., et al. 1982. J. Biol. Chem. 257: 3105-3109. PMID: 7061468

2. Langan, T.J. and Slater, M.C. 1991. J. Cell Physiol. 149: 284-292. PMID: 1748720

3: Ishii, S. and Volpe, J.J. 1987. J. Neurochem 49: 1606-1612. PMID: 3668542

Physical State :
Solid
에서 유래된 :
Streptomyces sp.
용해도 :
Soluble in water (partly miscible), alkaline water, pyridine, hot methanol, DMSO (>10 mg/ml), ethanol (5 mg/ml), butanol (slightly), and DMF. Insoluble in acetone, ethyl acetate, chloroform, benzene, and acidic water.
저장 :
Store at room temperature
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
YO7980200
Merck Index :
14: 9819
MDL Number :
MFCD00065709
Beilstein Registry :
6888090

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Tunicamycin (CAS 11089-65-9)  논문정보

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PMID: # 28536105  Ramírez-Peinado, S. et al. 2017. J. Cell. Sci. 130: 2251-2265.

PMID: # 25903460  Kim, AY. et al. 2015. BMC Genomics. 16: 338.

PMID: # 26040720  Khaminets, A. et al. 2015. Nature. 522: 354-8.

PMID: # 25824232  Li, R. et al. 2015. Antimicrob. Agents Chemother. 59: 3460-8.

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