PIG-C Activators
GPI anchor biosynthesis is a multifaceted mechanism, harmoniously orchestrated within cells. The tapestry of this complex process unveils a repertoire of chemicals that can interplay with its rhythm, potentially modulating the function of key players such as PIG-C. On one hand, Manumycin A, by virtue of its inhibitory action on farnesyl transferase, lays down a framework where the realm of protein prenylation interacts with GPI-anchored protein functions. This intersection offers a landscape where PIG-C's role might be influenced. Similarly, Progesterone, a molecule fundamental in several physiological processes, casts its influence on the GPI-anchor biosynthesis, signaling the possible modulation of PIG-C.
Piercing through the layers of cellular lipid metabolism, chemicals like Myriocin, Miltefosine, and Perifosine sculpt the lipid terrain, in turn casting shadows on GPI-anchored protein behavior and potentially PIG-C's operations. Furthermore, agents like Phenylarsine oxide and Curcumin offer a broader perspective, where the vast expanse of cellular pathways can indirectly weave into the narrative of PIG-C functionality. Not to be sidelined, the impacts of Fluconazole and MβCD delineate the intricate relationship between membrane cholesterol, lipid rafts, and GPI-anchored proteins, echoing the whispers of potential PIG-C modulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
An inhibitor of the enzyme farnesyl transferase. By impacting protein prenylation, it can affect GPI-anchored protein functioning, indirectly influencing PIG-C. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
A steroid hormone that, in specific contexts, may influence GPI-anchor biosynthesis and therefore might impact PIG-C activity. | ||||||
Myriocin (ISP-1) | 35891-70-4 | sc-201397 | 10 mg | $150.00 | 8 | |
Inhibits serine palmitoyltransferase, which can impact sphingolipid synthesis and potentially affect GPI biosynthesis and PIG-C activity. | ||||||
Alendronate acid | 66376-36-1 | sc-337520 | 5 g | $135.00 | 2 | |
A bisphosphonate that may influence isoprenoid biosynthesis, potentially impacting the GPI anchor synthesis pathway and PIG-C functionality. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $41.00 | 4 | |
Known to affect GPI-anchored protein functions, which might indirectly modulate PIG-C activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
It can affect various signaling pathways and cellular processes, which may have indirect influences on the GPI anchor biosynthesis and PIG-C activity. | ||||||
Miltefosine | 58066-85-6 | sc-203135 | 50 mg | $81.00 | 8 | |
Alters lipid metabolism and impacts GPI-anchored proteins, which might affect PIG-C functionality. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
Affects lipid metabolism, specifically sphingolipids, which might indirectly influence PIG-C activity. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $54.00 $84.00 | 14 | |
An antifungal that inhibits ergosterol synthesis, potentially affecting lipid rafts and GPI-anchored protein distribution, influencing PIG-C indirectly. | ||||||
D609 | 83373-60-8 | sc-201403 sc-201403A | 5 mg 25 mg | $189.00 $575.00 | 7 | |
Inhibits phosphatidylcholine-specific phospholipase C, potentially impacting GPI-anchored proteins and thus PIG-C activity. | ||||||