Molecular structure of Alendronate acid, CAS Number: 66376-36-1
Alendronate acid (CAS 66376-36-1)
See product citations (2)
Alternate Names:
4-Amino-1-hydroxybutane-1,1-diphosphonic Acid
Application:
Alendronate acid is an inhibitor of FDPS
CAS Number:
66376-36-1
Purity:
98%
Molecular Weight:
249.10
Molecular Formula:
C4H13NO7P2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Alendronate acid is an inhibitor of FDPS. It is a bisphosphonate that inhibits osteoclast-mediated bone resorption. Unlike pyrophosphate, the endogenous regulator of bone turnover to which it is chemically related, Alendronate acid specifically inhibits osteoclastic osteoclastic bone resorption, having no effect on mineralization of bone newly formed by osteoblasts.
Alendronate acid (CAS 66376-36-1) References
- Pharmacokinetics of alendronate. | Porras, AG., et al. 1999. Clin Pharmacokinet. 36: 315-28. PMID: 10384857
- Atypical femoral fracture after long-term alendronate treatment: report of a case evidenced with magnetic resonance imaging. | Kao, CM., et al. 2012. Kaohsiung J Med Sci. 28: 555-8. PMID: 23089322
- Rare association of anti-hu antibody positive paraneoplastic neurological syndrome and transitional cell bladder carcinoma. | Lukacs, S., et al. 2012. Case Rep Urol. 2012: 724940. PMID: 23320243
- A review of minodronic acid hydrate for the treatment of osteoporosis. | Tanishima, S. and Morio, Y. 2013. Clin Interv Aging. 8: 185-9. PMID: 23440003
- The potential impact of new effervescent alendronate formulation on compliance and persistence in osteoporosis treatment. | Invernizzi, M., et al. 2015. Aging Clin Exp Res. 27: 107-13. PMID: 24996788
- A prospective analytical study of the effects and adverse events of alendronate (Aldren70) treatment in Thai postmenopausal women. | Tienboon, P. and Jaruwangsanti, N. 2014. J Med Assoc Thai. 97: 621-8. PMID: 25137879
- Determination of pKa values of alendronate sodium in aqueous solution by piecewise linear regression based on acid-base potentiometric titration. | Ke, J., et al. 2016. J Pharm Anal. 6: 404-409. PMID: 29404010
- Dynamic expression of SMAD3 is critical in osteoblast differentiation of PDMCs. | Lin, HT., et al. 2019. Int J Mol Med. 43: 1085-1093. PMID: 30483761
- Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in chronic inflammatory demyelinating polyradiculoneuropathy: protocol of an international, randomised, double-blind, placebo-controlled trial (OPTIC). | Bus, SRM., et al. 2021. Trials. 22: 155. PMID: 33608058
- Effectiveness of bisphosphonates on bone mineral density in osteopenic postmenopausal women: A systematic review and network meta-analysis of randomized controlled trials. | Dong, SL., et al. 2021. Medicine (Baltimore). 100: e26715. PMID: 34397808
- Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis. | Fu, X., et al. 2022. Nat Commun. 13: 6528. PMID: 36319632
- How Efficient are Alendronate-Nano/Biomaterial Combinations for Anti-Osteoporosis Therapy? An Evidence-Based Review of the Literature. | Klara, J. and Lewandowska-Łańcucka, J. 2022. Int J Nanomedicine. 17: 6065-6094. PMID: 36510618
- Enhanced Cell Osteogenic Differentiation in Alendronate Acid and Flufenamic Acid Drug-Impregnated Nanoparticles of Mesoporous Bioactive Glass Composite Calcium Phosphate Bone Cement In Vitro. | Liu, SM., et al. 2023. Pharmaceuticals (Basel). 16: PMID: 37242463
Inhibitor of:
amelotin, ANKH, CD203a, cementum attachment protein, CEMP1, cHMGCS, COL28A1, DMP-1, DSPG3, Dymeclin, EBPBP β, EG668210, Epilysin, FDPS, Gm1045, GS1, HAPLN3, Hint3, HMG-2L1, HMG-4, HTPAP, ICMT, IDI2, Kal1, LLH1, LRRC17, LRRC33, MVD, NELL1, Nephrocalcin, NPT2, OCIL, OG2, Olr1591, ORG, OSCAR, osteocalcin, PGAP1, PHEX, PIG-M, PIG-V, PINLYP, PIPK III, PMVK, PTH, R-ras3, and TERE1.Activator of:
C20orf123, CAML, CD203a, DCHS1, GGTase-Iα, GGTase-IIβ, IFITM5, katacalcin, OPG, OSTF1, Otoconin 90, PI 3-kinase p85110, PIG-C, PIG-O, PIG-Q, PiT2, RANK, RCE1, RUNX2, and ZP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Alendronate acid, 5 g | sc-337520 | 5 g | $135.00 |