PIG-C Inhibitors
PIG-C inhibitors are a class of chemical compounds that target Phosphatidylinositol Glycan class C (PIG-C), an enzyme that plays a pivotal role in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. GPI anchors are glycolipid molecules that attach proteins to cell membranes, facilitating important cellular processes such as signal transduction, cell adhesion, and membrane protein localization. PIG-C is involved specifically in the transfer of N-acetylglucosamine to the growing GPI precursor, making it a crucial component in the synthesis pathway. The activity of PIG-C is essential for the proper assembly of GPI anchors, which are integral for the functionality of numerous cell surface proteins.
Research on PIG-C inhibitors has opened up avenues for understanding the complexities of GPI biosynthesis and the roles that GPI-anchored proteins play in various biological contexts. By inhibiting PIG-C, scientists can dissect the contributions of GPI-anchored proteins to cellular processes and delineate their functions in both normal physiology and in various cellular responses. The exploration of PIG-C inhibition allows for a deeper investigation into how the disruption of GPI anchor synthesis can affect cellular signaling pathways and membrane dynamics. Furthermore, studying the effects of these inhibitors provides insight into the mechanisms of protein anchoring to the cell membrane and how alterations in this process can influence cellular behavior. Overall, PIG-C inhibitors are valuable in advancing our understanding of GPI metabolism and its intricate relationship with cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent could hypothetically lead to the hypomethylation of the PIG-C gene's promoter region, potentially resulting in the downregulation of its transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
By inhibiting histone deacetylases, Trichostatin A could induce a more closed chromatin configuration at the PIG-C locus, which may decrease PIG-C gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid may downregulate PIG-C expression by altering the differentiation status of cells, leading to changes in gene expression profiles that include the PIG-C gene. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As a tyrosine kinase inhibitor, Genistein could disrupt intracellular signaling pathways, potentially leading to reduced transcriptional activity of the PIG-C gene. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
By inhibiting the mTOR pathway, Rapamycin could suppress cell growth and proliferation, possibly leading to a decrease in PIG-C protein levels as part of a broader reduction in protein synthesis. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine could disrupt endosomal acidification, which may indirectly result in the reduced expression of PIG-C, as the protein's stability and trafficking could be compromised. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide could lead to a general inhibition of protein synthesis, which would include a decrease in the synthesis of the PIG-C protein, resulting from blocked translation elongation. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D, by intercalating into DNA, could directly inhibit the transcription of PIG-C mRNA, leading to a significant decrease in the PIG-C protein levels. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate could induce hyperacetylation of histones at the PIG-C gene locus, potentially leading to reduced transcriptional activity and thereby lower levels of PIG-C expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate could decrease the expression of the PIG-C gene by inhibiting the synthesis of tetrahydrofolate, reducing the availability of one-carbon units necessary for purine and pyrimidine synthesis. | ||||||