PI 3-kinase p85β Inhibitors
PI 3-kinase p85β inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of phosphoinositide 3-kinase (PI 3-kinase) p85β. PI 3-kinases are a family of lipid kinases that play a crucial role in various cellular processes, including cell growth, proliferation, and survival. They are involved in the regulation of intracellular signaling pathways, particularly the PI3K/AKT/mTOR pathway, which is essential for controlling cell growth and metabolism. Within the PI 3-kinase family, p85β is a regulatory subunit that binds to the catalytic subunit of the kinase, p110, and modulates its activity.
PI 3-kinase p85β inhibitors are designed to selectively target and block the function of this specific regulatory subunit. By doing so, these inhibitors disrupt the activation of downstream signaling pathways, such as the AKT and mTOR pathways, which are associated with cell proliferation and survival. This targeted inhibition can have a significant impact on cellular processes, particularly in the context of diseases characterized by aberrant PI3K signaling, such as certain types of cancer and metabolic disorders. These inhibitors are valuable tools for researchers studying the molecular mechanisms underlying these diseases and have the ability to uncover new insights into the role of PI3K p85β in normal and pathological cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent, irreversible inhibitor of PI3K, binding covalently to the p110 subunit. This indirectly affects p85β, as it disrupts the activity of the entire PI3K complex. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, blocking the ATP binding site of the enzyme. This reduces PI3K activity and can indirectly lead to decreased expression of p85β. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, has been shown to inhibit PI3K activity. While its exact mechanism is not fully understood, it is believed to modulate the PI3K/Akt pathway, potentially affecting p85β. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been reported to inhibit PI3K activity, which may be attributed to its antioxidant properties. This can lead to reduced expression or activity of PI3K components, including p85β. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine is known to inhibit Class III PI3K, and while its primary target is not p85β, it can indirectly influence the PI3K/Akt pathway and potentially affect p85β expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, the active compound in turmeric, has been reported to inhibit PI3K activity. Its anti-inflammatory and antioxidant properties may contribute to this effect, potentially modulating p85β expression. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavonoid that has been shown to inhibit PI3K activity, which can lead to a decrease in p85β expression or activity as a part of the PI3K/Akt signaling pathway. | ||||||
WYE-354 | 1062169-56-5 | sc-364652 sc-364652A | 10 mg 50 mg | $286.00 $1200.00 | ||
WYE-354 is a kinase inhibitor that has been reported to target mTOR, a downstream effector of PI3K. By inhibiting mTOR, WYE-354 can indirectly influence the PI3K pathway and p85β expression. | ||||||
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $188.00 $199.00 | 2 | |
GDC-0941 is a potent inhibitor of PI3K, and its inhibition of the PI3K/Akt pathway can lead to reduced expression or activity of components such as p85β. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
ZSTK474 is an inhibitor of PI3K, and by suppressing the PI3K/Akt pathway, it can indirectly affect the expression or activity of p85β. | ||||||