PHD3 Activators
The group of compounds categorized as PHD3 Activators represents a range of chemicals that influence the activity of PHD3 indirectly through modulation of cellular oxygen sensing and related metabolic pathways. These compounds do not directly bind or activate PHD3; instead, they create a cellular environment that can lead to changes in PHD3 activity. Their primary mechanism of action involves altering the balance of factors and cofactors necessary for the proper functioning of PHD3 in response to hypoxic conditions.
Compounds such as Dimethyloxalylglycine (DMOG) and Cobalt Chloride function by stabilizing HIF-α, mimicking hypoxic conditions, and potentially leading to a compensatory increase in PHD3 activity as the cell attempts to restore oxygen homeostasis. Iron chelators like Desferrioxamine (DFO) and 2,2'-Dipyridyl indirectly influence PHD3 by affecting the availability of iron, a crucial cofactor for the enzyme. By modulating iron levels, these compounds can trigger cellular responses aimed at rebalancing PHD3 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $82.00 $295.00 $367.00 $764.00 | 25 | |
A cell-permeable prolyl-4-hydroxylase inhibitor that can stabilize HIF, potentially leading to a compensatory increase in PHD3 activity under normoxic conditions. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Mimics hypoxic conditions by stabilizing HIF-α, which may indirectly enhance PHD3 activity to restore oxygen homeostasis. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1039.00 $2866.00 $4306.00 $8170.00 | 19 | |
A chelator that mimics hypoxia by inhibiting HIF prolyl hydroxylase, potentially leading to an indirect upregulation of PHD3 in an attempt to re-establish normoxia. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $42.00 $102.00 $322.00 | 3 | |
Known to influence cellular oxygen consumption and mitochondrial function, potentially impacting PHD3 activity indirectly. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
As a form of vitamin B3, it can influence cellular metabolism and redox state, potentially affecting PHD3 activity. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $44.00 $74.00 $130.00 | ||
As an intermediate in the TCA cycle, succinate can affect cellular hypoxia responses, potentially modulating PHD3 activity. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $42.00 $56.00 $112.00 $224.00 | ||
Another TCA cycle intermediate, fumarate, can modulate HIF and hypoxia signaling, potentially affecting PHD3. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $32.00 $42.00 $62.00 $108.00 $184.00 $724.00 $2050.00 | 2 | |
A key substrate for PHD3, its availability can influence PHD3 activity in hypoxia signaling. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $40.00 $94.00 | ||
As a key metabolic intermediate, pyruvate can affect cellular oxygen sensing mechanisms, potentially influencing PHD3 activity. | ||||||
Sodium oxalate | 62-76-0 | sc-203396 sc-203396A | 100 g 500 g | $42.00 $136.00 | 5 | |
Competes with 2-oxoglutarate, affecting PHD3 activity indirectly by influencing its substrate availability. | ||||||