Molecular structure of α-Ketoglutaric Acid, CAS Number: 328-50-7
α-Ketoglutaric Acid (CAS 328-50-7)
See product citations (2)
Alternate Names:
2-Oxoglutaric acid; 2-Oxopentanedioic acid
Application:
α-Ketoglutaric Acid is a derivative of glutaric acid
CAS Number:
328-50-7
Purity:
≥98%
Molecular Weight:
146.10
Molecular Formula:
C5H6O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
α-Ketoglutaric Acid, also known as 2-Ketoglutaric Acid, is a derivative of glutaric acid and is an intermediate in the kreb′s cycle catalyzed by glutamate dehydrogenase enzyme on glutamate. α-Ketoglutaric acid has demonstrated physiological effects on cells and tissues through the inhibition of enzymes involved in energy metabolism. α-Ketoglutaric acid′s significance extends beyond energy metabolism, as it is involved in various biochemical processes that are essential for cellular function and homeostasis. It is involved in cellular signaling and regulation. It acts as a signaling molecule that can influence gene expression, cellular differentiation, and adaptation to changes in the cellular environment.
α-Ketoglutaric Acid (CAS 328-50-7) References
- Bacterial oxidation of dipicolinic acid. II. Identification of alpha-ketoglutaric acid and 3-hydroxydipicolinic acid and some properties of cell-free extracts. | KOBAYASHI, Y. and ARIMA, K. 1962. J Bacteriol. 84: 765-71. PMID: 14033954
- Photometric determination of alpha-ketoglutaric acid with diazotized sulphanilic acid. | Momose, T., et al. 1969. Talanta. 16: 1451-6. PMID: 18960656
- α-Ketoglutaric acid production by Yarrowia lipolytica and its regulation. | Kamzolova, SV., et al. 2012. Appl Microbiol Biotechnol. 96: 783-91. PMID: 22707058
- α-Ketoglutaric acid production from rapeseed oil by Yarrowia lipolytica yeast. | Kamzolova, SV. and Morgunov, IG. 2013. Appl Microbiol Biotechnol. 97: 5517-25. PMID: 23435985
- Bioconversion of l-glutamic acid to α-ketoglutaric acid by an immobilized whole-cell biocatalyst expressing l-amino acid deaminase from Proteus mirabilis. | Hossain, GS., et al. 2014. J Biotechnol. 169: 112-20. PMID: 24172254
- Enzymatic production of α-ketoglutaric acid from l-glutamic acid via l-glutamate oxidase. | Niu, P., et al. 2014. J Biotechnol. 179: 56-62. PMID: 24657922
- Separation of α-ketoglutaric acid and pyruvic acid from the culture broth of Yarrowia lipolytica WSH-Z06 by chromatographic methods. | Peng, X., et al. 2018. Biotechnol Prog. 34: 1370-1379. PMID: 30281948
- Development of glutaric acid production consortium system with α-ketoglutaric acid regeneration by glutamate oxidase in Escherichia coli. | Yang, SY., et al. 2020. Enzyme Microb Technol. 133: 109446. PMID: 31874692
- Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation. | Yuan, Y., et al. 2020. EMBO J. 39: e103304. PMID: 32104923
- Pathway engineering of Escherichia coli for α-ketoglutaric acid production. | Chen, X., et al. 2020. Biotechnol Bioeng. 117: 2791-2801. PMID: 32530489
- Optimization of medium composition and fermentation conditions for α-ketoglutaric acid production from biodiesel waste by Yarrowia lipolytica. | Kamzolova, SV. and Morgunov, IG. 2020. Appl Microbiol Biotechnol. 104: 7979-7989. PMID: 32749527
- Labile Photo-Induced Free Radical in α-Ketoglutaric Acid: a Universal Endogenous Polarizing Agent for In Vivo Hyperpolarized 13 C Magnetic Resonance. | Gaunt, AP., et al. 2022. Angew Chem Int Ed Engl. 61: e202112982. PMID: 34679201
- The study of skin hydration, anti-wrinkles function improvement of anti-aging cream with alpha-ketoglutarate. | Yang, F., et al. 2022. J Cosmet Dermatol. 21: 1736-1743. PMID: 34817909
- α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling. | Yuan, Y., et al. 2022. Sci Adv. 8: eabn2879. PMID: 35507647
- Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control. | Masip, J., et al. 2022. Front Immunol. 13: 822272. PMID: 35514981
Inhibitor of:
ALKBH7, ASL, BDH1, CKMT1B, DHTKD1, FAHD2A, FAHD2B, FIH-1, fumarate hydratase, GLT25D2, IRG1, LEPREL1, PCLN-1, PEPCK-M, PGAM4, PGM 1, and TMLH.Activator of:
α-KGD, β-1,4-Gal-T3, μ-crystallin, 4933437F05Rik, Aasdh, AASDHPPT, AASS, AATM, ACO2, ACSS3, AGT1, AGXT2, ALDH16A1, ALDH3A2, ALDH4A1, ALDH5A1, ALKBH4, ALKBH6, Aminoacylase-1, AMPD3, Biotin-NHS, BLVRB, C10orf65, CDO, CDO1, citrin, CKMT1A, COASY, COL23A1, COL28A1, COL6A2, COL9A2, CPO, CPVL, CPXM2, CSAD, CysRS, D2HGDH, DAAO, DHDH, DNC, E3BP, EEPD1, EG240549, EG623286, FAHD1, Ferrochelatase, FLJ43505, GAP1m, GCAT, GGCT, GLT25D1, GLYATL1, GLYATL2, GLYATL3, GlyRS, GOT1L1, GPD2, GPR80, GPR91, GPT2, Gulo, HAAO, HAL, HAO1, HAO2, HIBADH, HIF PHD3, HLCS, HMGCLL1, HSCARG_NMRAL1, HSDL1, IDH3A, IDH3B, IDH3G, IRP-1, JMJD7, KMO, KRTAP9-2, KRTAP9-8, KY peptidase, L2HGDH, LDH-B, LEPREL2, LIAS, liver FBPase, LOC283398, lysine, ME1, ME2, Meprin Aβ, MICAL1, MIPP, MMD2, MRP-S22, muscle FBPase, NaDC-3, NAT-5, NAT-8L, NDUFAB1, NDUFV3, NOL55, Npl1, OGFOD1, OGFOD3, OPN1LW, OSGEPL1, OTA, OTC, P4H-TM, pantophysin, PDP2, PDPR, PHD1, PHD3, PLP, PM20D1, PPC Synthetase, PPC-DC, PRODH, PTPN20A, QPCTL, QSER1, RMND1, RPUSD3, SAMC, sarcosine dehydrogenase, SDHC, SDR39U1, SerRSmt, SLC15A5, SLC25A11, SLC25A18, SLC25A25, SLC25A33, SLC25A36, SLC25A38, SLC25A41, SUCLG1, SUCLG2, SUCO, TDG, Tim23, Timm8a2, TKTL2, TNP1, TRH-DE, TUSC3, TYW4, UGP2, and ZADH2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Ketoglutaric Acid, 25 g | sc-208504 | 25 g | $32.00 | |||
α-Ketoglutaric Acid, 100 g | sc-208504A | 100 g | $42.00 | |||
α-Ketoglutaric Acid, 250 g | sc-208504B | 250 g | $62.00 | |||
α-Ketoglutaric Acid, 500 g | sc-208504C | 500 g | $108.00 | |||
α-Ketoglutaric Acid, 1 kg | sc-208504D | 1 kg | $184.00 | |||
α-Ketoglutaric Acid, 5 kg | sc-208504E | 5 kg | $724.00 | |||
α-Ketoglutaric Acid, 16 kg | sc-208504F | 16 kg | $2050.00 |