Molecular structure of Dimethyloxaloylglycine (DMOG), CAS Number: 89464-63-1
Dimethyloxaloylglycine (DMOG) (CAS 89464-63-1)
See product citations (25)
Alternate Names:
Dimethyloxaloylglycine (DMOG) also known as Dimethyloxallyl glycine; N-(methoxyoxoacetyl)-glycine methyl ester
Application:
Dimethyloxaloylglycine (DMOG) is an inhibitor of prolyl hydroxylase (PHD) and the asparaginyl hydroxylase factor inhibiting HIF (FIH) that upregulates HIF-1α and FLRG
CAS Number:
89464-63-1
Purity:
≥98%
Molecular Weight:
175.14
Molecular Formula:
C6H9NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Dimethyloxaloylglycine (DMOG) is an inhibitor of prolyl hydroxylase (PHD) and the asparaginyl hydroxylase factor inhibiting HIF (FIH). DMOG has been observed to upregulate hypoxia inducible factor-1α (HIF-1alpha) in HMEC-1 cells, attenuating redox factor 1 (REF-1). PHT cells exposed to DMOG were observed to upregulate the follistatin-like 3 (FSTL3) transcription. Attenuation of myocardial injury by DMOG was also demonstrated using a rabbit ischemia reperfusion model. In NGF deprived neurons, DMOG increased cell survival through inhibition of cytochrome c release.
Dimethyloxaloylglycine (DMOG) (CAS 89464-63-1) References
- Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. | Milkiewicz, M., et al. 2004. J Physiol. 560: 21-6. PMID: 15319416
- Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells. | Asikainen, TM., et al. 2005. Free Radic Biol Med. 38: 1002-13. PMID: 15780758
- Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. | Asikainen, TM., et al. 2005. Proc Natl Acad Sci U S A. 102: 10212-7. PMID: 16009933
- Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. | Lomb, DJ., et al. 2007. J Neurochem. 103: 1897-906. PMID: 17760870
- Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints. | Gelse, K., et al. 2008. Arthritis Res Ther. 10: R111. PMID: 18789153
- HIF-1 attenuates Ref-1 expression in endothelial cells: reversal by siRNA and inhibition of geranylgeranylation. | Loboda, A., et al. 2009. Vascul Pharmacol. 51: 133-9. PMID: 19524065
- Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes. | Brökers, N., et al. 2010. Cancer Sci. 101: 129-36. PMID: 19817749
- Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha. | Heinis, M., et al. 2010. Diabetes. 59: 662-9. PMID: 20009089
- DFO and DMOG up-regulate the expression of CXCR4 in bone marrow mesenchymal stromal cells. | Wu, Y., et al. 2013. Pharmazie. 68: 835-8. PMID: 24273889
- PHDs inhibitor DMOG promotes the vascularization process in the AV loop by HIF-1a up-regulation and the preliminary discussion on its kinetics in rat. | Yuan, Q., et al. 2014. BMC Biotechnol. 14: 112. PMID: 25543909
- A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression. | Zhdanov, AV., et al. 2015. Biochim Biophys Acta. 1847: 1254-66. PMID: 26143176
- Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis. | Tambuwala, MM., et al. 2015. J Control Release. 217: 221-7. PMID: 26385165
- Stabilization of Hypoxia-inducible Factor by DMOG Inhibits Development of Chronic Hypoxia-Induced Right Ventricular Remodeling. | Zhang, S., et al. 2016. J Cardiovasc Pharmacol. 67: 68-75. PMID: 26485211
- Treatment with an activator of hypoxia-inducible factor 1, DMOG provides neuroprotection after traumatic brain injury. | Sen, T. and Sen, N. 2016. Neuropharmacology. 107: 79-88. PMID: 26970014
- Genome-wide analysis of DNA methylation during antagonism of DMOG to MnCl2-induced cytotoxicity in the mouse substantia nigra. | Yang, N., et al. 2016. Sci Rep. 6: 28933. PMID: 27380887
Inhibitor of:
ALKBH5, ALKBH6, ASPHD2, cGKI alpha, COL1A1, D2HGDH, DPAGT1, FIH-1, Hbb-bh1, Hemoglobin α1, HIF PHD, HIF PHD2, HIF PHD3, HIF-1 alpha, JMJD2C, JMJD3, JMJD8, Jumonji, LEPREL1, LOC100040981, LRRC40, NO66, OGFOD2, OGFOD3, P4H-TM, P4HA2, PAPP-A2, PH-4, PHD1, PLU-1, Prolyl Hydroxylase, SEMA4B, TET2, TETRAN, TMLH, TSG-6, and UTY.Activator of:
4933422H20Rik, ADAMTS-1, ADAMTS-10, ADAMTS-12, ADAMTS-14, ADAMTS-16, ADAMTS-2, ADAMTS-3, ADAMTS-4, ADAMTS-8, ANG V, CA IX, CCDC18, CEP170, COL12A, COL20A1, COL6A, COL6A6, COL8A1, COMMD2, cytoglobin, Cytoplasmic CysRS, Differentiated Endothelial Cell Marker, Epo, FAM188B2, FLVCR, FRBZ1, FRG2C, Hbb-bh1, Hbb-y, Hemoglobin α, Hemoglobin δ, HIF-1 alpha, HIF-3α, HIGD1B, HILPDA, Histone cluster 1 H2BG, IdnK, JMJD2C, JMJD4, JMJD7, KIAA1143, LDH-AL6B, LOC100041004, LOXL2, LRIG3, MCT9, myoglobin, NDGR1, NDRG3, NPAL3, ORP150, PHD3, PIGF, PIGF-2, PlGF2, PRAMEF23, Reptin 52, SIAH-2, SIP1, Sox-12, SphK1, TACC1, TFR2, Thrombospondin 3, THUMPD3, TMCO5B, Transcription Factor, VEGF-D, VHL, WDR26, and Zuotin-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dimethyloxaloylglycine (DMOG), 10 mg | sc-200755 | 10 mg | $82.00 | |||
Dimethyloxaloylglycine (DMOG), 50 mg | sc-200755A | 50 mg | $295.00 | |||
Dimethyloxaloylglycine (DMOG), 100 mg | sc-200755B | 100 mg | $367.00 | |||
Dimethyloxaloylglycine (DMOG), 500 mg | sc-200755C | 500 mg | $764.00 |