Peroxin 19 Inhibitors
Chemical inhibitors of Peroxin 19 can function through various mechanisms that ultimately disrupt the protein's role in peroxisomal biogenesis, particularly affecting its lipidation process and membrane association. Triacsin C, by targeting long-chain acyl-CoA synthetase, leads to a shortage of acyl-CoAs, which are vital for the lipidation of Peroxin 19. Cerulenin and C75, both fatty acid synthase inhibitors, reduce the availability of fatty acids for acyl-CoA production, which is a prerequisite for the functional lipid modification of Peroxin 19. Similarly, Perhexiline and Etomoxir, which inhibit carnitine palmitoyltransferase 1, result in reduced fatty acid oxidation. This limits the production of acyl-CoAs, thus impairing the lipidation required for Peroxin 19 function. Malonyl-CoA acts as a natural inhibitory substrate for CPT1 and can elevate to levels that lead to a decrease in acyl-CoA pools, further inhibiting the lipidation process central to Peroxin 19's role.
Moreover, 2-Bromopalmitate directly inhibits fatty acid metabolism, which is crucial for acyl-CoA synthesis and the subsequent lipidation of Peroxin 19. Tunicamycin, while not directly affecting Peroxin 19, induces ER stress that can have a cascading effect on cellular protein trafficking, indirectly impeding Peroxin 19's peroxisomal protein import function. Brefeldin A disrupts Golgi apparatus function, and Monensin alters lysosomal and Golgi pH gradients, both of which are processes that can indirectly affect the transport and functioning of Peroxin 19. Trifluoperazine, through its antagonism of calmodulin, can interfere with calcium signaling pathways that have downstream effects on Peroxin 19's role in membrane dynamics. Finally, WY-14643, as a PPAR alpha agonist, can alter lipid metabolism, leading to changes in lipid species and quantities that are necessary for the optimal function of Peroxin 19, thus indirectly inhibiting the protein's activity in peroxisomal protein import.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $187.00 $843.00 | 14 | |
Triacsin C inhibits long-chain acyl-CoA synthetase, which is essential for the synthesis of acyl-CoAs that are necessary for the lipidation of PEX19, a step crucial for its function in peroxisomal biogenesis. Inhibition of acyl-CoA synthesis by Triacsin C leads to functional inhibition of PEX19 by preventing its post-translational modification and membrane association. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Cerulenin is a fatty acid synthase inhibitor. By inhibiting fatty acid synthesis, the availability of fatty acids for the formation of acyl-CoAs is reduced. This impedes the lipidation process of PEX19, which is necessary for its proper functioning in the import of peroxisomal membrane proteins, thus functionally inhibiting PEX19. | ||||||
C75 (racemic) | 191282-48-1 | sc-202511 sc-202511A sc-202511B | 1 mg 5 mg 10 mg | $72.00 $206.00 $290.00 | 9 | |
C75, a synthetic fatty acid synthase inhibitor, reduces the production of fatty acids. The subsequent decrease in fatty acid availability leads to a reduction in acyl-CoA pools. Because PEX19 requires lipidation for its function, C75's action results in the functional inhibition of PEX19 by limiting its lipid modification and membrane targeting. | ||||||
rac Perhexiline Maleate | 6724-53-4 | sc-460183 | 10 mg | $188.00 | ||
Perhexiline inhibits carnitine palmitoyltransferase (CPT1), a mitochondrial enzyme involved in fatty acid metabolism. By inhibiting CPT1, perhexiline can indirectly reduce the availability of fatty acids necessary for acyl-CoA production, thereby impairing the lipidation of PEX19 critical for its function. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $151.00 $506.00 | 3 | |
Etomoxir inhibits carnitine palmitoyltransferase (CPT1), which is involved in fatty acid oxidation. The inhibition of CPT1 leads to a decrease in acyl-CoA levels, which are needed for PEX19 lipidation, thus functionally inhibiting the protein by blocking its essential post-translational modification. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Malonyl-CoA is a natural inhibitory substrate of carnitine palmitoyltransferase (CPT1). Elevated levels of malonyl-CoA can inhibit CPT1, resulting in reduced fatty acid oxidation and thus decreased acyl-CoA pools. This can inhibit PEX19 function by limiting the necessary lipidation process for its activity. | ||||||
2-Bromohexadecanoic acid | 18263-25-7 | sc-251714 sc-251714A | 10 g 50 g | $53.00 $201.00 | 4 | |
2-Bromopalmitate is an inhibitor of fatty acid metabolism, including the synthesis of acyl-CoA derivatives. By inhibiting acyl-CoA synthetase, it reduces the production of acyl-CoAs critical for the lipidation of PEX19, leading to its functional inhibition. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation. While PEX19 is not glycosylated, tunicamycin-induced ER stress can disrupt overall cellular protein trafficking and indirectly inhibit the proper functioning of PEX19 in peroxisomal protein import. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus structure and function, which can indirectly affect the peroxisomal protein import by altering vesicular trafficking pathways and membrane composition, thereby functionally inhibiting PEX19's role in these processes. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that disrupts lysosomal and Golgi pH gradients. It indirectly affects peroxisomal function by disrupting vesicular traffic and lipid homeostasis, which is essential for PEX19 function in peroxisomal membrane protein import. | ||||||