rac Perhexiline Maleate (CAS 6724-53-4)
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rac Perhexiline maleate, the racemic form of perhexiline maleate, is extensively studied in the context of its interaction with the cytochrome P450 enzyme system, particularly the CYP2D6 and CYP2C19 isoenzymes, which are key to its metabolic pathway. This compound is instrumental in research focused on cellular energy metabolism and mitochondrial function, as it provides a window into the effects of metabolic modulation at the cellular level. It also plays a central role in cardiac research, where its influence on ion channels and electrophysiological properties of cardiac myocytes is of interest. The comparative analysis between the enantiomers in the racemic mixture enhances the understanding of stereoselective effects on the compound′s pathways, while the maleate salt improves the compound′s solubility and stability for experimental applications.
rac Perhexiline Maleate (CAS 6724-53-4) References
- Polymorphic hydroxylation of perhexiline in vitro. | Sørensen, LB., et al. 2003. Br J Clin Pharmacol. 55: 635-8. PMID: 12814462
- Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia. | Inglis, SC., et al. 2007. Pharmacogenet Genomics. 17: 305-12. PMID: 17429312
- Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline. | Davies, BJ., et al. 2008. Br J Clin Pharmacol. 65: 347-54. PMID: 17875193
- Relationship between plasma, atrial and ventricular perhexiline concentrations in humans: insights into factors affecting myocardial uptake. | Drury, NE., et al. 2014. Br J Clin Pharmacol. 77: 789-95. PMID: 24117487
- Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis. | Sirenko, O., et al. 2016. Assay Drug Dev Technol. 14: 381-94. PMID: 27494736
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
rac Perhexiline Maleate, 10 mg | sc-460183 | 10 mg | $188.00 |