Molecular structure of (+)-Etomoxir sodium salt, CAS Number: 828934-41-4
(+)-Etomoxir sodium salt (CAS 828934-41-4)
See product citations (3)
Alternate Names:
R(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
Application:
(+)-Etomoxir sodium salt is a PPARα agonist and an irreversible CPT-1 inhibitor
CAS Number:
828934-41-4
Purity:
≥98%
Molecular Weight:
320.74
Molecular Formula:
C15H18ClO4•Na
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(+)-Etomoxir sodium salt is a chiral compound that functions as a reversible inhibitor of carnitine palmitoyltransferase I (CPT-1). CPT-1 is an enzyme responsible for the transport of long-chain fatty acids into the mitochondria, where they are metabolized to generate energy. The sodium salt of (+)-Etomoxir has found extensive use in scientific research for in vitro applications, for investigating the effects of CPT-1 inhibition on various biological activities, as well as the biochemical and physiological implications. In addition, (+)-Etomoxir sodium salt is a PPARα activator and an inhibitor of β-oxidation in mitochondria.
(+)-Etomoxir sodium salt (CAS 828934-41-4) References
- Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells. | Zhang, J., et al. 2012. Nat Protoc. 7: 1068-85. PMID: 22576106
- Fatty acid carbon is essential for dNTP synthesis in endothelial cells. | Schoors, S., et al. 2015. Nature. 520: 192-197. PMID: 25830893
- The role of fatty acid β-oxidation in lymphangiogenesis. | Wong, BW., et al. 2017. Nature. 542: 49-54. PMID: 28024299
- Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells. | Thomas, M., et al. 2018. Cell Biochem Funct. 36: 65-79. PMID: 29399832
- Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism. | Schönke, M., et al. 2018. J Lipid Res. 59: 1276-1282. PMID: 29739863
- Assessment of Brown Adipocyte Thermogenic Function by High-throughput Respirometry. | Mahdaviani, K., et al. 2015. Bio Protoc. 5: PMID: 29770346
- Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation. | Wang, W., et al. 2020. Oxid Med Cell Longev. 2020: 5849794. PMID: 32256954
- Anti-Trypanosoma cruzi Activity of Metabolism Modifier Compounds. | Martinez-Peinado, N., et al. 2021. Int J Mol Sci. 22: PMID: 33445756
- TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2. | Trimarco, JD., et al. 2021. PLoS Pathog. 17: e1009599. PMID: 34043740
- Sorting-free metabolic profiling uncovers the vulnerability of fatty acid β-oxidation in in vitro quiescence models. | Ortmayr, K. and Zampieri, M. 2022. Mol Syst Biol. 18: e10716. PMID: 36094015
Inhibitor of:
4921528O07Rik, ABHD15, ABHD5, ACAA1, Acaa1b, ACAD, ACAD-11, ACAD-12, ACADVL, ACBD6, acetyl-CoA acyltransferase 2 (ACAA2), Acnat2, ACOT10, ACOT12, ACOT2, ACOT3, ACOT4, ACOT5, ACOT6, ACOT8, ACOT9, ACOX1, ACSBG2, ACSF3, ACSL6, ACSM2A, ACSM2B, ACSM4, ACSM5, ACSS1, ACSS3, ACSVL2, ACSVL4, ACSVL5, AWAT1, Carnitine Acetyltransferase, CDS1, CIDE-C, CLS1, CPTI-L, CPTI-M, CROT, D10Jhu81e, D10Wsu102e, Dbil5, DECR1, ECHDC2, ECHDC3, ECHS1, FABP12, FAM57B, FATP-1, FATP4, G3PP, GBGT1, GDPD4, GLYATL3, GNPAT, GPD1, HADHSC, HIBCH, iGb3, L-FABP, LPAAT-α, LPAAT-β, LPAAT-δ, MAMSTR, MCAD, MDGI, Mecr, Mimp, MULK, MUP, PAT2, PE, Peroxin 19, PHYHIPL, PLEKHS1, SCD2, SKIP, SLC25A29, SLMO2, StARD7, TFIIH p62, THEM2, THEM5, TMEM195, TMPPE, Tom70, Tomm20l, and ZAG.Activator of:
Acnat1, ACOT6, ACSVL4, CDV, Centaurin γ3, PDK4, PGS1, PIG-X, PKC λ/Δ, PPAR alpha, and RPRD2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-Etomoxir sodium salt, 5 mg | sc-215009 | 5 mg | $148.00 | |||
(+)-Etomoxir sodium salt, 25 mg | sc-215009A | 25 mg | $496.00 |