Peroxin 19 Antibody (2E4): sc-517578

Peroxin 19 Antibody (2E4) is a mouse monoclonal IgG2a kappa light chain antibody that detects Peroxin 19 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Peroxin 19 antibody (2E4) is available in non-conjugated form. Peroxin 19, also known as peroxisomal farnesylated protein or PxF, plays a crucial role in peroxisome biogenesis, essential for cellular metabolism and fatty acid breakdown. Peroxin 19 is primarily located on the cytoplasmic surface of peroxisomes, particularly in liver cells, where Peroxin 19 is involved in initial stages of peroxisome membrane assembly. Proper localization of Peroxin 19 facilitates matrix protein import necessary for peroxisome function. The carboxy-terminal region of Peroxin 19, containing the CAAX homology box, is critical for biological activity, underscoring structural integrity importance in cellular processes. The gene encoding Peroxin 19 is a housekeeping gene located on human chromosome 1q22 and is associated with complementation group J peroxisome biogenesis disorder, highlighting significance in human health and disease.

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Peroxin 19 Antibody (2E4) References:

1. Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly.  |  Matsuzono, Y., et al. 1999. Proc Natl Acad Sci U S A. 96: 2116-21. PMID: 10051604
2. Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes.  |  Biermanns, M. and Gärtner, J. 2001. Biochem Biophys Res Commun. 285: 649-55. PMID: 11453642
3. cDNA cloning and characterization of the third isoform of human peroxin Pex11p.  |  Tanaka, A., et al. 2003. Biochem Biophys Res Commun. 300: 819-23. PMID: 12559946
4. Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism.  |  Chen, H., et al. 2010. Hum Mol Genet. 19: 494-505. PMID: 19933170
5. Zellweger syndrome and associated brain malformations: report of a novel Peroxin1 (PEX1) mutation in a Native American infant.  |  Mohebbi, MR., et al. 2012. J Child Neurol. 27: 1589-92. PMID: 22378672
6. Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase.  |  Aparicio, D., et al. 2013. J Biol Chem. 288: 11907-19. PMID: 23482565
7. Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.  |  You, L., et al. 2020. Virulence. 11: 537-553. PMID: 32434419
8. Primary Human Trabecular Meshwork Model for Pseudoexfoliation.  |  Chakraborty, M., et al. 2021. Cells. 10: PMID: 34943956
9. PxF, a prenylated protein of peroxisomes.  |  James, GL., et al. 1994. J Biol Chem. 269: 14182-90. PMID: 8188701
10. Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein.  |  Kammerer, S., et al. 1997. Genomics. 45: 200-10. PMID: 9339377
11. Pex19p, a farnesylated protein essential for peroxisome biogenesis.  |  Götte, K., et al. 1998. Mol Cell Biol. 18: 616-28. PMID: 9418908
12. Newly identified Chinese hamster ovary cell mutants are defective in biogenesis of peroxisomal membrane vesicles (Peroxisomal ghosts), representing a novel complementation group in mammals.  |  Kinoshita, N., et al. 1998. J Biol Chem. 273: 24122-30. PMID: 9727033

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Peroxin 19 Antibody (2E4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Peroxin 19 Antibody (2E4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Peroxin 19 Antibody (2E4) Specifications

Alternate Product Name: Peroxin 19

Product Clone Name: 2E4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-299

Epitope Target: Peroxin 19

Epitope Species: human

Product Reactivity/Detection: Peroxin 19

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Peroxin 19 Antibody (2E4): N/A