Per 2 Activators
Per 2 activators are a spectrum of chemical compounds that advance the functional activity of Per 2 by targeting several signaling mechanisms and epigenetic modifications. Forskolin, by elevating cAMP, and Sildenafil Citrate, by enhancing cGMP, both contribute to the phosphorylation and stabilization of Per 2, a critical element in the circadian rhythm control. Lithium Chloride's inhibition of GSK-3β prevents the phosphorylation and subsequent degradation of Per 2, thereby bolstering its activity. In the realm of epigenetic influence, Trichostatin A and Sodium Butyrate impede histone deacetylases, leading to a transcriptionally open state at the PER2 locus and thus amplifying Per 2 expression. Complementarily, 5-Azacytidine reduces DNA methylation at the PER2 gene, further facilitating its transcription and the resultant protein's activities.
Resveratrol and Nicotinamide Riboside, by activating SIRT1, promote the deacetylation and activation of Per 2, fine-tuning circadian oscillations. Curcumin's supportive role in the CLOCK-BMAL1 complex formation indirectly potentiates Per 2 function, vital for the circadian feedback loop. Additionally, Retinoic Acid's interaction with its receptors may enhance PER2 gene expression, indirectly promoting Per 2 activity. Sulforaphane induces Nrf2, leading to a reduction in oxidative stress that can negatively impact Per 2 stability, thus indirectly supporting its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing the levels of cAMP. Elevated cAMP enhances the Per 2 by promoting phosphorylation events that are crucial for its stability and nuclear translocation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, which can phosphorylate and destabilize Per 2. Inhibition of GSK-3β stabilizes Per 2, thereby enhancing its activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to the hyperacetylation of histones near the PER2 gene, resulting in enhanced chromatin accessibility and subsequent elevated function of Per 2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that may induce hypomethylation of the DNA at the PER2 gene locus, enhancing its transcription and indirectly increasing the activity of Per 2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which can deacetylate and positively regulate the function of Per 2, leading to enhanced circadian rhythm regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to influence circadian rhythm through modulation of CLOCK and BMAL1 interaction; it may enhance Per 2 activity by stabilizing the circadian loop where Per 2 is a crucial component. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside increases NAD+ levels, which is a substrate for SIRT1. SIRT1 can then positively regulate Per 2 by deacetylation, leading to enhanced function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid can influence circadian gene expression by binding to retinoic acid receptors that interact with the regulatory elements of PER2, potentially enhancing Per 2 activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2 which can lead to the antioxidant response element (ARE) driven expression of detoxifying enzymes. This can indirectly stabilize Per 2 by reducing oxidative stress that may destabilize it. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that may increase histone acetylation at the PER2 gene, enhancing its expression and thus indirectly increasing Per 2 activity. | ||||||