Per 2 Inhibitors
Chemical inhibitors of Per 2 can disrupt the protein's function through various molecular mechanisms, primarily by interfering with signaling pathways that regulate circadian rhythms. SCH-28080 targets the H+/K+ ATPase function, thereby potentially disturbing proton gradients that are essential for cellular processes integral to Per 2's role in the timing system. This disruption can lead to an altered state of Per 2 activity. Similarly, PD-98059 and U0126 inhibit the MEK enzymes within the MAPK signaling pathway, which is a critical modulator of circadian rhythms. By inhibiting MEK, these chemicals can prevent the proper signaling required for Per 2's normal function within the circadian clock. LY-294002's action as a PI3K inhibitor affects the phosphorylation status of various proteins by impeding a pathway that is involved in the regulation of circadian rhythms, which includes Per 2.
Further, SP600125 as a JNK inhibitor, and SB203580 as a p38 MAPK inhibitor, can alter the functioning of Per 2 by obstructing the stress response pathways that also contribute to the regulatory mechanisms of the circadian clock. The inhibitors K252a, GF-109203X, and Ro-31-8220, which target protein kinase C (PKC), disrupt intracellular signaling that is necessary for the proper functioning of Per 2. H-89 and KT-5720, both inhibitors of protein kinase A (PKA), similarly change the phosphorylation state of Per 2, which is a post-translational modification crucial for its activity. Lastly, KN-93's inhibition of CaMKII affects calcium signaling within the cell, which has a significant influence on the regulation of circadian rhythms and, consequently, the activity of Per 2. These chemical inhibitors, through their targeted action on various kinases and enzymes, can effectively alter the functional state of Per 2 within the circadian regulatory framework.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD-98059 is an inhibitor of MEK, which in turn is part of the MAPK signaling pathway. As Per 2 is involved in the circadian clock, which is affected by various signaling pathways including MAPK, PD-98059 can inhibit the pathway that modulates circadian rhythm, thereby functionally inhibiting Per 2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, a kinase that can influence circadian rhythm by affecting cellular responses to stress and other signals. JNK pathway inhibition by SP600125 can alter the functioning of clock proteins such as Per 2. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, another kinase that is involved in stress responses and can affect circadian clock regulation. Inhibition of p38 MAPK by SB203580 can thus functionally inhibit Per 2 by disrupting the signaling pathways it is involved in. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK1/2, which are upstream regulators of ERK in the MAPK pathway. Since the MAPK pathway is known to interact with cellular circadian rhythm components, U0126 can inhibit signaling that would otherwise influence Per 2 function. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
K252a is a kinase inhibitor with specificity towards protein kinase C (PKC), which is involved in the signaling pathways that regulate circadian rhythms. By inhibiting PKC, K252a can disrupt signals that are necessary for the proper functioning of Per 2. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
GF-109203X is a selective inhibitor of protein kinase C, and by inhibiting PKC, it can disrupt the intracellular signaling that influences the function of proteins involved in circadian rhythm, including Per 2. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $138.00 $220.00 $972.00 | 47 | |
KT-5720 is another PKA inhibitor, and by inhibiting PKA, it can prevent the phosphorylation and the subsequent activity of certain proteins that control circadian rhythms, such as Per 2. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). CaMKII influences intracellular calcium levels that are crucial for the regulation of circadian rhythms, and thus, KN-93 can inhibit the proper functioning of Per 2. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro-31-8220 is a potent PKC inhibitor, which affects the phosphorylation of proteins within the signaling pathways that govern circadian rhythms. By inhibiting PKC, Ro-31-8220 can functionally inhibit Per 2 by disrupting the signaling network it operates within. | ||||||