PCGF1 Activators
PCGF1, also known as Polycomb Group Ring Finger 1, is a member of the Polycomb group (PcG) proteins, which are essential regulators of gene expression and chromatin structure. PCGF1 acts as a core component of several Polycomb repressive complexes (PRCs), including PRC1. PCGF1 plays a crucial role in mediating transcriptional repression by PRC1 through the ubiquitination of histone H2A at lysine 119 (H2AK119ub1), resulting in the compaction of chromatin structure and the inhibition of gene expression. Additionally, PCGF1 is involved in diverse cellular processes, including cell cycle regulation, DNA repair, and stem cell maintenance, highlighting its significance in development and disease.
Activation of PCGF1 is tightly regulated by multiple mechanisms that control its recruitment, assembly into PRC1 complexes, and enzymatic activity. One key regulatory mechanism involves post-translational modifications, such as phosphorylation, acetylation, and ubiquitination, which modulate PCGF1's interactions with other PRC1 subunits and chromatin-binding partners. Furthermore, the expression levels and subcellular localization of PCGF1 can be influenced by various signaling pathways and environmental cues, thereby regulating its availability and function. Additionally, the formation of higher-order protein complexes, such as PRC1 and PRC2, and their interplay with chromatin modifiers and transcriptional regulators, contribute to the dynamic regulation of PCGF1 activity. Overall, elucidating the mechanisms of PCGF1 activation provides crucial insights into the regulation of gene expression and chromatin dynamics during development and disease processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs), which can lead to a more open chromatin structure and may indirectly enhance the function of PCGF1 in gene silencing. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This DNA methyltransferase inhibitor can cause demethylation of DNA, potentially creating conditions that favor the recruitment and functional enhancement of PCGF1 in chromatin remodeling. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
As a methyl donor, it can contribute to the methylation of histones, which might indirectly increase the ability of PCGF1 to bind to chromatin and exert its gene silencing function. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit proteasome activity, possibly leading to accumulation of proteins involved in the ubiquitin-proteasome pathway, which might enhance the functional activity of PCGF1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can lead to increased levels of ubiquitinated proteins, potentially enhancing the ubiquitin-related functions of PCGF1 in epigenetic regulation. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide can modulate NF-κB pathway, which might affect the cellular environment in a way that indirectly enhances the activity of PCGF1 in gene silencing. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
As a cofactor for histone demethylases, Vitamin C can alter histone methylation status, potentially affecting PCGF1's interaction with chromatin. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that could alter signaling pathways, potentially leading to an environment that enhances the function of PCGF1 in gene repression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane affects histone deacetylases (HDACs) activity, which could indirectly enhance PCGF1 function by affecting chromatin structure and gene expression profiles. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
By influencing gene expression and cellular differentiation, Retinoic Acid might create a context that indirectly increases the functional activity of PCGF1 in repressing specific target genes. | ||||||