p73α Activators
The p73α protein is a pivotal transcription factor belonging to the p53 family, which is renowned for its role in cellular processes such as cell cycle control, apoptosis, and genomic stability. Despite sharing structural similarities with p53, p73α has unique attributes and functions, particularly in neuronal development and differentiation. The TP73 gene, responsible for encoding p73α, undergoes complex alternative splicing, producing various isoforms with distinct biological roles. The TAp73 isoform, for example, is a potent inducer of apoptosis and can function in a compensatory manner when p53 activity is compromised. The diverse roles of p73α extend to cellular stress responses, where it can initiate programs leading to cell cycle arrest or cell death in response to DNA damage, thereby upholding genomic integrity.
Recent studies have identified a myriad of small molecular weight compounds that can potentially induce the expression of p73α. These activators encompass a wide range of naturally occurring and synthetic molecules, each with unique mechanisms of action. Compounds like resveratrol, found in grapes, and sulforaphane, present in cruciferous vegetables, are believed to enhance p73α expression by triggering intrinsic cellular antioxidant pathways, which can lead to a cascade of reactions resulting in the upregulation of protective genes. Other molecules, such as the DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine, can cause epigenetic alterations that result in the activation of otherwise silent genes, including TP73. Additionally, phytochemicals like curcumin and flavonoids such as quercetin and genistein are known to induce the expression of p73α through various non-receptor mediated pathways, which involve changes in gene expression and cellular adaptation to stress. These diverse activators highlight the intricate network of intracellular signaling pathways that converge on the regulation of p73α, showcasing the complexity of gene expression control within the cellular milieu.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may upregulate p73α expression through activation of sirtuin pathways, which have been shown to interact with members of the p53 protein family, leading to potential increases in apoptotic signaling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane can stimulate the expression of p73α by initiating an antioxidant response that alters gene expression profiles, particularly those related to cellular stress responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to induce the expression of p73α by altering histone modifications and DNA methylation states, leading to changes in gene expression patterns associated with cell cycle control. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can stimulate the transcription of p73α through its action on specific antioxidant-responsive elements within the genome, which are responsible for initiating protective cellular responses. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is capable of increasing p73α levels by engaging with pathways related to the estrogen receptor, which can cross-talk with genes responsible for cell cycle regulation and apoptosis. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine may induce the expression of p73α by hypomethylating the promoter region of the TP73 gene, which consequently leads to the reactivation of epigenetically silenced genes. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol can promote p73α expression by interacting with the Vitamin D receptor, which may have downstream effects on the transcriptional activity of genes involved in growth arrest and apoptosis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may enhance the expression of p73α by binding to its receptors, which then bind to retinoic acid response elements in the genome, influencing gene transcription including that of TP73. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine has the potential to stimulate p73α expression by promoting oxidative stress, which can lead to a cascade of cellular signals culminating in the activation of apoptotic pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate from green tea is thought to upregulate p73α via its antioxidant properties, which can trigger a series of intracellular events linked to cell survival and death pathways. | ||||||