p73α Inhibitors
p73α inhibitors are a class of chemical compounds that specifically target the p73α isoform of the p73 protein, a member of the p53 family of transcription factors. The p73 protein plays a crucial role in regulating cell cycle progression, apoptosis, and cellular differentiation. The α isoform, p73α, is distinguished by its unique C-terminal domain, which influences its transcriptional activity and protein interactions. By inhibiting p73α, researchers can investigate the specific functions and regulatory mechanisms associated with this isoform, gaining insights into its role in various physiological and cellular processes. This selective inhibition is essential for dissecting the complex signaling pathways in which p73α is involved and understanding its impact on gene expression and cellular responses.
Chemically, p73α inhibitors vary in structure but generally function by binding to specific domains of the p73α protein, such as the DNA-binding domain or the oligomerization domain. This binding interferes with the protein's ability to interact with DNA or other molecular partners necessary for its transcriptional activity. Some inhibitors may mimic natural ligands or adopt conformations that disrupt the protein's structural integrity, thereby inhibiting its function. The study of p73α inhibitors involves examining their binding affinities, specificity, and the structural requirements for effective inhibition. These compounds are valuable tools in biochemical and cellular assays, allowing scientists to explore the dynamics of p73α activity, its regulatory networks, and its role in cellular homeostasis. Understanding how these inhibitors interact with p73α contributes to the broader knowledge of protein function modulation and the design of molecules with high specificity and potency.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib targets and inhibits PARP enzymes, which play a role in DNA repair mechanisms. Inhibition of these enzymes can result in the accumulation of DNA damage, leading to a potential downregulation of p73α expression as a cellular response to the genetic instability. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid acts as a histone deacetylase (HDAC) inhibitor, leading to increased acetylation of histones. This alteration in chromatin structure can cause a specific decrease in the transcription of genes, including potentially the gene encoding p73α. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide has been shown to inhibit translation initiation, which could specifically reduce the levels of p73α protein by preventing its mRNA from being effectively translated on the ribosomes. | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $251.00 | 10 | |
UCN-01 is a kinase inhibitor that may disrupt several cell signaling cascades, leading to a decrease in p73α expression as these signaling cascades could be involved in the transcriptional regulation of the p73α gene. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that induces DNA strand breaks. This DNA damage can trigger a cellular response that includes the downregulation of certain genes, potentially including the gene for p73α. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
As a DNA intercalating agent, ellipticine can obstruct the transcriptional machinery, leading to a specific decrease in the expression of genes such as p73α by physically blocking the transcription process. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is known to suppress the transcription by interfering with RNA polymerase II activity, which could lead to a targeted reduction in p73α mRNA synthesis and subsequent protein expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib, by inhibiting the proteasome, leads to the accumulation of proteins destined for degradation. This proteostasis disruption can lead to a cellular stress response that includes the downregulation of certain proteins, potentially including p73α. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid triggers mitochondrial apoptosis pathways, which could involve the targeted downregulation of proteins like p73α as part of the cell's commitment to apoptosis. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to specific DNA sequences and inhibits RNA polymerase, which could result in a specific decrease in the transcription of the p73α gene. | ||||||