P2X7 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A 438079 hydrochloride | 899507-36-9 | sc-203788B sc-203788 sc-203788C sc-203788A | 5 mg 10 mg 25 mg 50 mg | $125.00 $215.00 $430.00 $785.00 | 13 | |
A 438079 hydrochloride acts as a selective antagonist for the P2X7 receptor, exhibiting unique binding characteristics that disrupt ATP-mediated signaling. Its structural conformation allows for precise interactions with the receptor's allosteric sites, influencing ion flow and cellular excitability. The compound demonstrates a rapid onset of action, with a distinct kinetic profile that alters receptor desensitization and enhances the modulation of inflammatory pathways. | ||||||
Brilliant Blue G | 6104-58-1 | sc-203733 sc-203733A | 5 g 25 g | $39.00 $99.00 | 11 | |
Brilliant Blue G serves as a potent modulator of the P2X7 receptor, characterized by its ability to stabilize receptor conformation and inhibit ATP-induced channel opening. Its unique molecular structure facilitates specific interactions with key amino acid residues, altering ion permeability and downstream signaling cascades. The compound exhibits a notable affinity for the receptor, leading to altered kinetics in receptor activation and desensitization, thereby influencing cellular responses to extracellular ATP. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $136.00 | 20 | |
KN-62 is a selective antagonist of the P2X7 receptor, distinguished by its ability to disrupt ATP-mediated signaling pathways. Its unique binding profile allows it to interact with specific allosteric sites, modulating receptor activity and influencing ion flow dynamics. The compound exhibits rapid kinetics, effectively altering the receptor's activation threshold and desensitization patterns, which can significantly impact cellular calcium influx and subsequent signaling events. | ||||||
A 740003 | 861393-28-4 | sc-291774 sc-291774A | 10 mg 50 mg | $176.00 $733.00 | 8 | |
A 740003 is a potent antagonist of the P2X7 receptor, characterized by its selective inhibition of ATP-induced receptor activation. This compound engages with unique binding sites, leading to alterations in receptor conformation and ion permeability. Its kinetic profile reveals a swift onset of action, effectively modulating the receptor's response to extracellular ATP. Additionally, A 740003 influences downstream signaling cascades, impacting cellular responses to inflammatory stimuli. | ||||||
A 804598 | 1125758-85-1 | sc-396064 | 5 mg | $104.00 | ||
A 804598 is a selective antagonist of the P2X7 receptor, distinguished by its ability to disrupt ATP-mediated signaling pathways. This compound exhibits a unique binding affinity that stabilizes the inactive conformation of the receptor, thereby preventing ion channel opening. Its interaction kinetics suggest a rapid dissociation rate, allowing for dynamic modulation of receptor activity. Furthermore, A 804598 alters downstream calcium signaling, influencing cellular excitability and inflammatory responses. | ||||||
GW 791343 hydrochloride | 309712-55-8 | sc-203992 sc-203992A | 10 mg 50 mg | $175.00 $739.00 | ||
GW 791343 hydrochloride is a potent antagonist of the P2X7 receptor, characterized by its selective inhibition of ATP-induced receptor activation. This compound engages in specific molecular interactions that favor the stabilization of the receptor's closed state, effectively blocking ion flux. Its unique reaction kinetics reveal a slow onset of action, which may lead to prolonged modulation of receptor-mediated pathways. Additionally, GW 791343 hydrochloride influences downstream signaling cascades, impacting cellular responses to extracellular stimuli. | ||||||
A 839977 | 870061-27-1 | sc-362707 sc-362707A | 10 mg 50 mg | $199.00 $810.00 | 1 | |
A 839977 is a selective P2X7 receptor antagonist that exhibits unique binding dynamics, favoring a conformational shift that prevents receptor activation by ATP. Its interaction profile suggests a high affinity for the receptor's allosteric sites, leading to altered ion channel behavior. The compound demonstrates distinct reaction kinetics, with a rapid onset of inhibition, allowing for immediate modulation of cellular signaling pathways. This specificity enhances its potential to influence various physiological processes. | ||||||
Adenosine 5′-triphosphate, periodate oxidized sodium salt | 71997-40-5 | sc-214508 sc-214508A | 25 mg 100 mg | $234.00 $754.00 | ||
Adenosine 5'-triphosphate, periodate oxidized sodium salt, acts as a potent modulator of the P2X7 receptor, exhibiting unique interaction characteristics that influence receptor desensitization. Its oxidized form alters the binding affinity for ATP, resulting in a distinct kinetic profile that enhances the receptor's ion permeability. This compound's ability to stabilize specific conformations of the receptor may lead to novel pathways in cellular signaling, impacting downstream effects on inflammation and cell death. | ||||||