GW 791343 hydrochloride CAS: 309712-55-8
MF: C20H24F2N4O•3HCl
MW: 483.81
A P2X7 allosteric modulator.

GW 791343 hydrochloride (CAS 309712-55-8)

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Synonym: 2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride
Application: A P2X7 allosteric modulator
CAS Number: 309712-55-8
Molecular Weight: 483.81
Molecular Formula: C20H24F2N4O•3HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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GW 791343 hydrochloride is a P2X7 allosteric modulator. Exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). A positive allosteric modulator of rat P2X7. GW 791343 hydrochloride is an inhibitor of P2X7.


References

Michel et al (2008) Negative and positive allosteric modulators of the P2X7 receptor. Br.J.Pharmacol. 153 737. Michel et al (2008) Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects. Br.J.Pharmacol. 155 738.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Boiling Point :
565.4° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9848159
MDL Number :
MFCD12828767
SMILES :
CC1=C(C=C(C=C1)CN2CCNCC2)NC(=O)CNC3=CC(=C(C=C3)F)F.Cl.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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