A 438079 hydrochloride CAS: 899507-36-9
MF: C13H9Cl2N5•HCl
MW: 342.61
A competitive P2X7 receptor antagonist that is inactive at other P2 receptors.

A 438079 hydrochloride (CAS 899507-36-9)

A 438079 hydrochloride | CAS 899507-36-9 is rated 5.0 out of 5 by 1.
  • y_2020, m_3, d_31, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203788, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 132ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride
Application: A competitive P2X7 receptor antagonist that is inactive at other P2 receptors
CAS Number: 899507-36-9
Purity: ≥98%
Molecular Weight: 342.61
Molecular Formula: C13H9Cl2N5•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 >> 10 µM). Possesses antinociceptive activity in models of neuropathic pain in vivo.


References

Nelson et al (2006) Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J.Med.Chem. 49 3659. Donnelly-Roberts and Jarvis (2007) Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br.J.Pharmacol. 151 571. McGaraughty et al (2007) P2X7-related modulation of pathological nociception in rats. Neuroscience 146 1817.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Boiling Point :
525.1° C at 760 mmHg (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11688742
SMILES :
C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

A 438079 hydrochloride  Product Citations

See how others have used A 438079 hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 26739809  2016. Sci Rep. 6: 19108.

PMID: # 22986947  2013. Toxicol. Sci. 131: 325-35.

PMID: # 22865777  Ito, G. et al. 2013. Eur J Pain. 17: 185-199.

PMID: # 22343416  Chatterjee, S. et al. 2012. Free Radic. Biol. Med. 52: 1666-79.

PMID: # 21763420  Ohshima, Y. et al. 2011. Free Radic. Biol. Med. 51: 1240-1248.

PMID: # 19171786  Díaz-Hernández, M. et al. 2009. FASEB J. 23: 1893-1906.

Citations 1 to 6 of 6 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 163ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Chatterjee Chatterjee, S. et al. (PubMed 22343416) used product sc-203788 (A 438079 hydrochloride), a competitive P2X7 receptor antagonist, to demonstrate the role of P2X7 receptors in Kupffer cell activation and generation of protein radicals due to oxidative stress. Found that in the presence of sc-203788 Kupffer cell activation was blocked, reducing oxidative stress and free radicals. -SCBT Publication Review
Date published: 2015-07-13
  • y_2020, m_3, d_31, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203788, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 21ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.