Molecular structure of A 740003, CAS Number: 861393-28-4
A 740003 (CAS 861393-28-4)
See product citations (8)
Alternate Names:
N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]- 2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
Application:
A 740003 is a potent, selective and competitive P2X7 receptor antagonist
CAS Number:
861393-28-4
Purity:
≥98%
Molecular Weight:
474.56
Molecular Formula:
C26H30N6O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A 740003 is a competitive antagonist of P2X7 receptors that may act to potently block proinflammatory cytokine interleukin-1beta (IL-1beta) release. Experiments have reported that a slight activation of P2X7 receptors causes a rapid increase in the opening of non-selective cation channels. P2X7 receptors are ATP-sensitive and localized on cells of immunological origin.
A 740003 (CAS 861393-28-4) References
- A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. | Honore, P., et al. 2006. J Pharmacol Exp Ther. 319: 1376-85. PMID: 16982702
- Novel P2X7 receptor antagonists ease the pain. | King, BF. 2007. Br J Pharmacol. 151: 565-7. PMID: 17471176
- Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. | Donnelly-Roberts, DL., et al. 2009. Br J Pharmacol. 157: 1203-14. PMID: 19558545
- P2X₇-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells. | Grol, MW., et al. 2012. Am J Physiol Endocrinol Metab. 302: E561-75. PMID: 22185840
- Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [¹¹C]A-740003 as a novel tracer of neuroinflammation. | Janssen, B., et al. 2014. J Labelled Comp Radiopharm. 57: 509-16. PMID: 24995673
- Activation of P2X7 receptors in the midbrain periaqueductal gray of rats facilitates morphine tolerance. | Xiao, Z., et al. 2015. Pharmacol Biochem Behav. 135: 145-53. PMID: 26054441
- Role of P2X7R in the development and progression of pulmonary hypertension. | Yin, J., et al. 2017. Respir Res. 18: 127. PMID: 28646872
- A cyclic pathway of P2 × 7, bradykinin, and dopamine receptor activation induces a sustained articular hyperalgesia in the knee joint of rats. | Teixeira, JM., et al. 2018. Inflamm Res. 67: 301-314. PMID: 29260240
- Activation of the P2X7 receptor in midbrain periaqueductal gray participates in the analgesic effect of tramadol in bone cancer pain rats. | Li, P., et al. 2018. Mol Pain. 14: 1744806918803039. PMID: 30198382
- Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis. | Xiao, Z., et al. 2022. Mol Pain. 18: 17448069221106844. PMID: 35748325
- ATP ion channel P2X purinergic receptors in inflammation response. | Liu, JP., et al. 2023. Biomed Pharmacother. 158: 114205. PMID: 36916431
- P2X and P2Y receptor antagonists reduce inflammation in ATP-induced microglia. | Imraish, A., et al. 2023. Pharm Pract (Granada). 21: 2788. PMID: 37090457
Inhibitor of:
P2X1, P2X3, P2X5, and P2X7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 740003, 10 mg | sc-291774 | 10 mg | $176.00 | |||
A 740003, 50 mg | sc-291774A | 50 mg | $733.00 |