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A 740003 is a competitive antagonist of P2X7 receptors that has been shown to potently block proinflammatory cytokine interleukin-1β (IL-1β) release. Experiments have reported that a slight activation of P2X7 receptors causes a rapid increase in the opening of non-selective cation channels. P2X7 receptors are ATP-sensitive and localized on cells of immunological origin.
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3. Donnelly-Roberts, D.L., et al. 2009. Br. J. Pharmacol. 157: 1203-1214. PMID: 19558545
See how others have used A 740003. Click on the entry to view the PubMed entry .
PMID: # 30138927 Piippo, N. et al. 2018. Cell. Physiol. Biochem. 49: 359-367.
PMID: # 21505260 Kim, JE. et al. 2011. J. Clin. Invest. 121: 2037-47.
PMID: # 27122036 J. Neurosci. 36: 4785-801.
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