Brilliant Blue G CAS: 6104-58-1
MF: C47H48N3O7S2•Na
MW: 854.02
A commonly used analytical biochemistry dye and P2X7 antagonist.

Brilliant Blue G (CAS 6104-58-1)

Brilliant Blue G | CAS 6104-58-1 is rated 5.0 out of 5 by 1.
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Synonym: Coomassie Brilliant Blue G (CBBG)
Application: A commonly used analytical biochemistry dye and P2X7 antagonist
CAS Number: 6104-58-1
Molecular Weight: 854.02
Molecular Formula: C47H48N3O7S2•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Brilliant Blue G (CBBG) is a member of the Coomassie dye family and is commonly used in analytical biochemistry to stain proteins in SDS-PAGE and BN-PAGE. CBBG is a useful component in the Bradford Method, a dye-binding protein assay employed to determine protein concentration in a given solution. CBBG can exist in three forms: a cation (red form with maximum absorbance at 470 nm), a neutral form (green with maximum at 650 nm), and an anionic form (blue with maximum at 595 nm). The anionic form initiates a stable complex with basic amino acid residues, mainly arginine and aromatic amino acids. Although the anionic form exists in negligible concentrations at the assay reaction mixture's pH, the protein-binding shifts the equilibrium toward its formation. Recent research reveals CBBG as a P2X7 (P2X purinoceptor 7: P2RX7) antagonist and suggests that it exhibits neuroprotective properties in rat spinal cord cells.


References

1. Bradford, M.M. 1976. Anal. Biochem. 72: 248-254. PMID: 942051
2. Schägger, H. and von Jagow, G. 1991. Anal. Biochem. 199: 223-231. PMID: 1812789
3. Matejovicova, M., et al. 1997. Anal. Biochem. 245: 252-254. PMID: 9056222
4. Brum, A.M., et al. 2006. Am. J. Vet. Res. 67: 358-362. PMID: 16454645
5. Wang, X., et al. 2007. Biotechnol. Lett. 29: 1599-1603. PMID: 17563857
6. Peng, W., et al. 2009. Proc. Natl. Acad. Sci. U.S.A. 106: 12489-12493. PMID: 19666625
7. Su, Z.Q., et al. 2010. Pharm Biol. 48: 966-973. PMID: 20731546

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (40 mg/ml at 20° C), methanol, ethanol (40 mg/ml), DMSO (~10 mg/ml), and DMF (~0.5 mg/ml).
Storage :
Store at room temperature
Melting Point :
>100° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6324599
MDL Number :
MFCD00078482
EC Number :
228-058-4
Beilstein Registry :
5230822
SMILES :
CCN(CC1=CC(=CC=C1)S(=O)(=O)[O-])C2=CC(=C(C=C2)/C(=C/3\\C=CC(=[N+](CC)CC4=CC(=CC=C4)S(=O)(=O)[O-])C=C3C)/C5=CC=C(C=C5)NC6=CC=C(C=C6)OCC)C.[Na+]

Download SDS (MSDS)

Certificate of Analysis

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Brilliant Blue G  Product Citations

See how others have used Brilliant Blue G. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 28669743  Caglayan, B. et al. 2017. Exp. Neurol. 296: 23-31.

PMID: # 17543993  Xu, F. et al. 2007. Neurosci. Lett. 420: 179-183.

PMID: # 16675591  Nicolle, G. et al. 2006. Clin. Cancer Res. 12: 2937-2943.

PMID: # 16772337  Wu, Y.L. et al. 2006. J Cell Sci. 19: 2797-2806.

PMID: # 14633698  Zetser, A. et al. 2003. Cancer Res. 63(22): 7733-7741.

PMID: # 12853035  Al Haj Zen, A. et al. 2003. Matrix Biol. 22: 251-258.

PMID: # 12954809  Marcet-Palacios, M. et al. 2003. J. Pharmacol. Exp. Ther. 307: 429-436.

PMID: # 11918217  Pommerenke, H. et al. 2002. J. Bone Miner. Res. 17: 603-611.

Citations 1 to 8 of 8 total
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Rated 5 out of 5 by from Various publications cite the use of Brilliant Various publications cite the use of Brilliant Blue G in staining gels or in protein concentration assays. -SCBT Publication Review
Date published: 2015-07-07
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