Molecular structure of A 804598, CAS Number: 1125758-85-1
A 804598 (CAS 1125758-85-1)
Alternate Names:
N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine
Application:
A 804598 is a P2X7 antagonist
CAS Number:
1125758-85-1
Purity:
≥98%
Molecular Weight:
315.37
Molecular Formula:
C19H17N5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A 804598 functions as a potent inhibitor of a specific enzyme involved in cellular signaling pathways. It exerts its mechanism of action by binding to the active site of the enzyme, thereby preventing its normal function and disrupting downstream signaling cascades. This disruption ultimately leads to the modulation of various cellular processes, including gene expression, cell proliferation, and apoptosis. By targeting this specific enzyme, A 804598 has the ability to influence the behavior of cells in experimental applications. Its precise mechanism of action at the molecular level allows for the interrogation of specific signaling pathways and the elucidation of their roles in cellular physiology.
A 804598 (CAS 1125758-85-1) References
- The impact of the P2X7 receptor antagonist A-804598 on neuroimmune and behavioral consequences of stress. | Catanzaro, JM., et al. 2014. Behav Pharmacol. 25: 582-98. PMID: 25083574
- Involvement of the P2X7 purinergic receptor in colonic motor dysfunction associated with bowel inflammation in rats. | Antonioli, L., et al. 2014. PLoS One. 9: e116253. PMID: 25549098
- Isobolographic Analysis of Drug Combinations With Intrathecal BRL52537 (κ-Opioid Agonist), Pregabalin (Calcium Channel Modulator), AF 353 (P2X3 Receptor Antagonist), and A804598 (P2X7 Receptor Antagonist) in Neuropathic Rats. | Jung, YH., et al. 2017. Anesth Analg. 125: 670-677. PMID: 28277328
- The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice. | Geraghty, NJ., et al. 2017. Purinergic Signal. 13: 405-415. PMID: 28597172
- The role of microglial P2X7: modulation of cell death and cytokine release. | He, Y., et al. 2017. J Neuroinflammation. 14: 135. PMID: 28716092
- ATP induces PAD4 in renal proximal tubule cells via P2X7 receptor activation to exacerbate ischemic AKI. | Rabadi, M., et al. 2018. Am J Physiol Renal Physiol. 314: F293-F305. PMID: 29021225
- P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet. | Freire, D., et al. 2019. J Neuroimmune Pharmacol. 14: 263-277. PMID: 30353422
- The P2X7 receptor (P2X7R)-specific antagonist A804598 inhibits inflammatory reaction in human fibroblast-like synoviocytes. | Liu, Y., et al. 2020. Am J Transl Res. 12: 45-53. PMID: 32051736
- P2X7R antagonists in chronic stress-based depression models: a review. | von Muecke-Heim, IA., et al. 2021. Eur Arch Psychiatry Clin Neurosci. 271: 1343-1358. PMID: 34279714
- Protective Effect of Purinergic P2X7 Receptor Inhibition on Acrolein-Induced Urothelial Cell Damage. | Taidi, Z., et al. 2022. Front Physiol. 13: 885545. PMID: 35492615
- ATP ion channel P2X purinergic receptors in inflammation response. | Liu, JP., et al. 2023. Biomed Pharmacother. 158: 114205. PMID: 36916431
- The human P2X7 receptor alters microglial morphology and cytokine secretion following immunomodulation. | von Mücke-Heim, IA., et al. 2023. Front Pharmacol. 14: 1148190. PMID: 37101546
- [Drug-induced allergic skin reactions of a cutaneous vascular type (author's transl)]. | Pevny, I. and Röckl, H. 1975. MMW Munch Med Wochenschr. 117: 9-16. PMID: 804598
Inhibitor of:
P2X7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 804598, 5 mg | sc-396064 | 5 mg | $102.00 |