p18SRP Activators
p18SRP activators encompass a variety of chemical compounds that interface with distinct cellular signaling pathways, ultimately leading to an increase in its functional activity. For instance, certain small molecules are known to directly stimulate adenylate cyclase or act as cAMP analogs, resulting in elevated cAMP levels within the cell. This surge in cAMP activates protein kinase A (PKA), which in turn can phosphorylate substrates that either directly or indirectly associate with p18SRP, thereby enhancing its activity. Moreover, beta-adrenergic agonists contribute to this regulatory landscape by fostering cAMP production through receptor-mediated signaling, further potentiating the PKA-dependent pathways that facilitate p18SRP activation.
In addition to cAMP-related mechanisms, other activators exert their influence through modulation of intracellular calcium levels. Ionophores that increase the cellular calcium concentration can activate calcium-dependent kinases, which are capable of phosphorylating and thereby activating p18SRP. Moreover, certain inhibitors of protein phosphatases lead to increased phosphorylation levels within the cell, potentially altering the functional state of p18SRP. This altered phosphoprotein environment can enhance p18SRP's activity by changing its interaction dynamics with other signaling molecules.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-specific inhibitor of phosphodiesterases, leading to increased cAMP levels, indirectly upregulating p18SRP activity by reducing its degradation through cAMP-dependent pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
Analog of cAMP that activates PKA, which can then phosphorylate substrates that may include regulatory elements of p18SRP, enhancing its activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Beta-adrenergic agonist that indirectly increases p18SRP activity via cAMP production and subsequent activation of PKA-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activator of protein kinase C, which may lead to phosphorylation events that enhance the activity of p18SRP by modulating its interaction with other proteins. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium levels, which can activate calcium-dependent kinases that phosphorylate and activate p18SRP. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore that elevates intracellular calcium levels, potentially activating p18SRP through calcium-mediated signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Cell-permeable cAMP analog that activates PKA, potentially enhancing p18SRP activity through phosphorylation of associated regulatory proteins. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Selective inhibitor of phosphodiesterase 4, increasing cAMP levels and thereby potentiating p18SRP activity through a PKA-dependent mechanism. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Inhibits protein synthesis at the translational level, which can lead to stress responses that upregulate p18SRP activity through MAPK pathway activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation and potential activation of p18SRP through altered signaling dynamics. | ||||||