OVOL3 Activators
OVOL3 play a pivotal role in modulating the activity of this protein, which is integral to various cellular processes. Retinoic Acid, by engaging in retinoic acid signaling, can regulate differentiation and proliferation in epithelial tissues, thereby fostering an environment conducive to OVOL3 activation. Similarly, All-trans-Retinal can lead to increased synthesis of retinoic acid, which subsequently activates OVOL3. Lithium Chloride functions by inhibiting GSK-3 beta, which might otherwise repress OVOL3 activity, promoting epithelial differentiation. Forskolin's role in raising intracellular cAMP levels enhances the PKA signaling pathway, indirectly stimulating OVOL3 activity crucial for epidermal morphogenesis. In parallel, Dibutyryl cAMP, a cAMP analogue, penetrates cellular membranes to activate cAMP-dependent pathways, thus promoting OVOL3 function.
Epidermal Growth Factor initiates a signaling cascade via its receptor that culminates in OVOL3 activation, integral to epidermal differentiation and proliferation. Trichostatin A, by inhibiting histone deacetylases, allows a more accessible chromatin configuration around the OVOL3 promoter, facilitating its activation. The reduction of DNA methylation near the OVOL3 gene through the action of 5-Azacytidine enhances transcription factor binding and OVOL3 activation. Conversely, PMA activates OVOL3 by stimulating protein kinase C, which phosphorylates transcription factors that aid in OVOL3's role in cellular differentiation. Spermidine promotes OVOL3 activity by inducing autophagy and protein translation, including that of factors activating OVOL3. Lastly, LY294002 and Rapamycin modulate OVOL3 through their inhibitory actions on PI3K and mTOR, respectively, which leads to altered signaling pathways that support OVOL3 activation, thus playing a part in the regulation of cellular differentiation and development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid activates OVOL3 by engaging in retinoic acid signaling, which can regulate differentiation and proliferation in epithelial tissues where OVOL3 functions. This signaling leads to changes in the cellular environment that favor OVOL3 activation for its role in cellular differentiation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride activates OVOL3 by inhibiting GSK-3 beta, which in turn may prevent the phosphorylation of transcription factors that repress OVOL3 activity allowing OVOL3 to maintain its function in promoting epithelial differentiation and development. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates OVOL3 by increasing intracellular cAMP levels, which can enhance the PKA signaling pathway. PKA can phosphorylate transcription factors or coactivators that stimulate OVOL3 activity, which is critical for its role in epidermal morphogenesis and repair. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
Dibutyryl cAMP activates OVOL3 by serving as a membrane-permeable analogue of cAMP, thus enhancing the cAMP-dependent pathways that can promote OVOL3 activation which is involved in the regulation of keratinocyte differentiation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A activates OVOL3 by inhibiting histone deacetylases, leading to a more relaxed chromatin structure around the OVOL3 promoter region, which can facilitate transcription factor access and activation of OVOL3 in its role in skin development and differentiation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine activates OVOL3 by inhibiting DNA methyltransferase, thereby reducing methylation near the OVOL3 gene, which can lead to enhanced transcription factor binding and activation of OVOL3, a key player in epithelial-to-mesenchymal transition. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates OVOL3 by activating protein kinase C (PKC), which can then phosphorylate and activate transcription factors or signaling molecules that promote the function of OVOL3 in cellular differentiation processes. | ||||||
all-trans Retinal | 116-31-4 | sc-210778A sc-210778 | 250 mg 1 g | $126.00 $372.00 | 7 | |
All-trans-Retinal activates OVOL3 by interacting with retinaldehyde dehydrogenase, an enzyme involved in retinoic acid synthesis, potentially leading to an increase in retinoic acid which can activate OVOL3 through retinoid signaling pathways associated with development. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine activates OVOL3 by inducing autophagy and enhancing protein translation, which can include the translation of factors that activate OVOL3, thereby supporting its function in promoting epithelial cell differentiation and tissue development. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 activates OVOL3 by inhibiting PI3K, which alters the downstream AKT signaling pathway. This can lead to a cellular environment that supports OVOL3 activation, as OVOL3 is implicated in the regulation of processes affected by PI3K/AKT signaling. | ||||||