OTTMUSG00000016788 Inhibitors
Histone cluster 2 family member (H2al1g) is a key player in chromatin remodeling and gene expression regulation within the cell nucleus. To inhibit the function of H2al1g, various chemical compounds have been identified, each with its distinct mode of action. Vorinostat, also known as SAHA, stands as a direct inhibitor of H2al1g. This compound operates by blocking the deacetylation of histones, a critical process in chromatin regulation. Consequently, Vorinostat's intervention results in alterations to chromatin structure, hindering H2al1g's ability to modulate gene expression effectively. Additionally, 5-Aza-2'-deoxycytidine acts as an indirect inhibitor of H2al1g by targeting DNA methyltransferases. By diminishing DNA methylation, this compound triggers changes in chromatin architecture, which in turn influences gene expression patterns. This interference ultimately leads to the inhibition of H2al1g's ability to function efficiently in orchestrating gene regulation within the cellular context. JQ1, on the other hand, operates indirectly by disrupting bromodomain interactions with acetylated histones, thereby affecting chromatin structure and gene regulation. SB203580 takes an indirect route as well, inhibiting the p38 mitogen-activated protein kinase (MAPK) pathway. This disruption impacts chromatin remodeling and gene expression regulation, leading to functional inhibition of H2al1g.
GSK-J4 operates through indirect inhibition by affecting histone methylation patterns, ultimately leading to changes in chromatin structure and gene expression. MG-132, a proteasome inhibitor, indirectly inhibits H2al1g by preventing the degradation of ubiquitinated proteins, influencing protein turnover within chromatin. PFI-1, a bromodomain inhibitor targeting BET proteins, operates indirectly by disrupting bromodomain interactions with acetylated histones, thus affecting chromatin structure and gene regulation. Finally, Rapamycin, as an mTOR inhibitor, acts indirectly by interfering with the mTOR signaling pathway, impacting chromatin remodeling and gene expression. These diverse chemical inhibitors function through both direct and indirect mechanisms, either by binding directly to H2al1g or by influencing crucial cellular pathways involved in chromatin regulation. Through these interventions, they effectively inhibit the functional capacity of H2al1g, contributing to our understanding of the intricate regulatory processes governing gene expression within the nucleus.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid, also known as SAHA, is a histone deacetylase (HDAC) inhibitor. It directly inhibits H2al1g by preventing the deacetylation of histones, leading to alterations in chromatin structure. As a result, H2al1g's capacity to modulate gene expression is impeded, ultimately resulting in functional inhibition. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine is a DNA methyltransferase inhibitor. It indirectly inhibits H2al1g by reducing DNA methylation, which can lead to altered chromatin structure and gene expression patterns, ultimately inhibiting the protein's function. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a bromodomain and extraterminal domain (BET) protein inhibitor. It indirectly inhibits H2al1g by disrupting bromodomain interactions with acetylated histones, affecting chromatin structure and gene regulation, leading to functional inhibition of the protein. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 mitogen-activated protein kinase (MAPK). It indirectly inhibits H2al1g by interfering with the p38 MAPK pathway, which can impact chromatin remodeling and gene expression, resulting in the functional inhibition of H2al1g. | ||||||
Tris Buffered Saline: 1 L of 1X | sc-362185 | 1 L | $21.00 | 3 | ||
Tubacin is a histone deacetylase 6 (HDAC6) inhibitor. It directly inhibits H2al1g by preventing the deacetylation of specific substrates, impacting chromatin remodeling and gene expression regulation, ultimately leading to the functional inhibition of H2al1g. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to modulate various signaling pathways, including those related to inflammation and oxidative stress. It indirectly inhibits H2al1g by influencing these pathways, which can impact chromatin structure and gene expression, resulting in the functional inhibition of the protein. | ||||||
GSK-J4 | 1373423-53-0 | sc-507551 | 100 mg | $1275.00 | ||
GSK-J4 is a histone demethylase inhibitor. It indirectly inhibits H2al1g by affecting histone methylation patterns, which can lead to changes in chromatin structure and gene expression, resulting in the functional inhibition of the protein. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor. It indirectly inhibits H2al1g by preventing the degradation of ubiquitinated proteins, affecting protein turnover within chromatin, and leading to the functional inhibition of H2al1g. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can modulate multiple cellular pathways, including those involved in oxidative stress response and cell survival. It indirectly inhibits H2al1g by influencing these pathways, which can impact chromatin structure and gene expression, resulting in the functional inhibition of the protein. | ||||||
ITF2357 | 732302-99-7 | sc-364513 sc-364513A | 5 mg 50 mg | $340.00 $1950.00 | ||
Givinostat is a histone deacetylase (HDAC) inhibitor. It directly inhibits H2al1g by preventing the deacetylation of histones, leading to alterations in chromatin structure. As a result, H2al1g's capacity to modulate gene expression is impeded, ultimately resulting in functional inhibition. | ||||||