Molecular structure of ITF2357, CAS Number: 732302-99-7
ITF2357 (CAS 732302-99-7)
Alternate Names:
Givinostat
Application:
ITF2357 is a potent inhibitor of HDAC with IC50 of 7.5-16 nM
CAS Number:
732302-99-7
Molecular Weight:
475.97
Molecular Formula:
C24H27N3O4•HCl•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TF2357 (Givinostat) is a potent inhibitor of HDAC with IC50 of 7.5-16 nM. ITF2357 reduces the release of TNFα, IL-1α, IL-1β, and IFNγ, in PBMCs with IC50 of 10-25 nM, respectively. ITF2357 activates the intrinsic apoptotic pathway, up-regulates p21 and down-regulates Bcl-2 and Mcl-1. ITF2357 inhibits the production of IL-6, VEGF, and IFNγ in mesenchymal stromal cells (MSCs) by 80-95%. ITF2357 favors β-cell survival during inflammatory conditions. ITF2357 at concentrations of 25 and 250 nM increases islet cell viability, enhances insulin secretion, inhibits release of MIP-1α and MIP-2, reduces NO production and decreases apoptosis rates.
ITF2357 (CAS 732302-99-7) References
1. Leoni F, et al. Mol Med, 2005, 11(1-12), 1-15. 2. Golay J, et al. Leukemia, 2007,21(9), 1892-1900. 3. Lewis EC, et al. Mol Med, 2011, 17(5-6), 369-377. 4. Shein NA, et al. FASEB J, 2009, 23(12), 4266-4275.Inhibitor of:
AHDC1, Dpy30, E47, H2BFWT, HDA2, HDAC, HDAC11, Histone cluster 1 H1C, Histone cluster 1 H1E, Histone cluster 1 H2AG, Histone cluster 1 H3B, Histone cluster 1 H4, Histone cluster 1 H4H, Histone cluster 1 H4L, Histone cluster 2 H2AA3, Histone cluster 2 H2AC, Histone cluster 2 H3C1, Histone cluster 2 H4, Histone H2A.Bbd, Histone H3, LIN-53, LOC665622, MORF4L2, Mxi 1, NKAP, NWD1, NY-REN-34, OTTMUSG00000016788, OTTMUSG00000016789, OTTMUSG00000016790, OTTMUSG00000016887, OTTMUSG00000018481, OTTMUSG00000018888, p150, PAGE-2, RP23-480B19.10, SDS3, Slfn5, TAF II p70, TAF6L, TSSC4, and YEATS2.Activator of:
2900008C10Rik, ATF-7IP, BAF, BRD3, EG546205, HDA1, Histone cluster 1 H2A, Histone cluster 1 H2AM, Histone cluster 1 H2B, Histone cluster 1 H2BC, Histone cluster 1 H3H, Histone H1B, MOF, PABPC4, RASSF1, SMARCD2, and Trimethyl Histone H3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ITF2357, 5 mg | sc-364513 | 5 mg | $340.00 | |||
ITF2357, 50 mg | sc-364513A | 50 mg | $1950.00 |