OSTM1 Activators
OSTM1 Activators broadly refer to chemical compounds that can influence the function of the OSTM1 protein, either directly or indirectly. The activation of OSTM1 is particularly associated with the modulation of the NF-κB signaling pathway, a crucial cellular pathway involved in inflammation, immunity, and cell survival. OSTM1, or osteopetrosis-associated transmembrane protein 1, is an integral membrane protein that is known to have a role in the function of osteoclasts, cells involved in the normal resorption of bone tissue. The OSTM1 protein forms a complex with the chloride channel protein CLCN7, and this complex is crucial for the acidification of the resorption lacuna, which is necessary for bone resorption.
Activators of OSTM1 can encompass a range of chemical entities that either directly interact with the OSTM1 protein to enhance its stability, promote its expression, or facilitate its interaction with partner proteins such as CLCN7. Direct activators can bind to OSTM1 and stabilize its conformation, thereby increasing its efficacy in forming functional complexes with CLCN7. This stabilization can enhance the acidification capacity of osteoclasts, thereby indirectly affecting bone resorption processes. Indirect activators of OSTM1 include signaling molecules that upregulate the transcription of the OSTM1 gene, leading to increased protein synthesis. These can be transcription factor agonists that bind to promoter regions upstream of the OSTM1 coding sequence. Alternatively, compounds that inhibit negative regulators of OSTM1 also constitute indirect activators. For instance, inhibiting a protein that targets OSTM1 for degradation result in elevated levels of the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is known to inhibit GSK3β, which in turn can modulate the NF-κB pathway. OSTM1 is a component of the NF-κB signaling pathway, thus, inhibition of GSK3β can lead to increased activation of OSTM1. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin inhibits cyclooxygenase enzymes, which results in decreased prostaglandin production. This leads to modulation of the NF-κB pathway, and since OSTM1 is a part of this pathway, aspirin serves as an indirect activator of OSTM1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a potent inhibitor of NF-κB activation. By inhibiting NF-κB activation, it can lead to a compensatory increase in OSTM1 activation, assuming that OSTM1 acts as a negative regulator within this pathway. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a HDAC inhibitor that can increase the acetylation and subsequent activation of NF-κB, which can have an impact on OSTM1, a component of the NF-κB signaling pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is an activator of SIRT1, which can inhibit NF-κB signaling. This could lead to a compensatory increase in OSTM1 activation, assuming that OSTM1 acts as a negative regulator within this pathway. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 irreversibly inhibits the TNF-α-induced activation of IκBα, thereby inhibiting the activation of NF-κB. This inhibition can influence OSTM1 if it operates as a negative regulator within the NF-κB pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that inhibits the activation of NF-κB. This inhibition can lead to increased activation of OSTM1, assuming that OSTM1 acts as a negative regulator within this pathway. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is an isothiocyanate that activates Nrf2, which in turn can inhibit NF-κB signaling. This can lead to a compensatory increase in OSTM1 activation, assuming that OSTM1 is a negative regulator within this pathway. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is a sesquiterpene lactone that inhibits NF-κB activation. This inhibition can lead to increased activation of OSTM1, assuming that OSTM1 acts as a negative regulator within this pathway. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1, which can inhibit NF-κB signaling. This inhibition can lead to increased activation of OSTM1, assuming that OSTM1 is a negative regulator within this pathway. | ||||||