OSTM1 Antibody (4H1): sc-293366

OSTM1 Antibody (4H1) is a mouse monoclonal IgG2a kappa light chain antibody that detects OSTM1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-OSTM1 antibody (4H1) is available as a non-conjugated antibody. OSTM1, also known as osteopetrosis associated transmembrane protein 1, gl (gray-lethal), or HSPC019, is a 338 amino acid single-pass type I membrane protein predominantly expressed in osteoclasts and melanocytes, as well as in the brain, kidney, and spleen. OSTM1 plays a crucial role in the regulation of osteoclast function, which is essential for bone remodeling and homeostasis. Disruptions in OSTM1 function can lead to bone autosomal recessive osteopetrosis (ARO), a severe hereditary bone disease characterized by abnormally dense bone due to defective resorption of immature bone. ARO is linked to mutations in the OSTM1 gene and manifests in two forms: a severe autosomal recessive form that occurs in utero, infancy, or childhood, and a benign autosomal dominant form that appears in adolescence or adulthood. Additionally, defects in the OSTM1 gene are responsible for the spontaneous gl mutant, which causes a coat color defect in mice. OSTM1 (4H1) antibody′s ability to effectively detect this important protein makes OSTM1 (4H1) antibody a valuable tool for research into bone diseases and related conditions.

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OSTM1 Antibody (4H1) References:

1. The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation/function.  |  Rajapurohitam, V., et al. 2001. Bone. 28: 513-23. PMID: 11344051
2. Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human.  |  Chalhoub, N., et al. 2003. Nat Med. 9: 399-406. PMID: 12627228
3. [Osteopetrosis, from mouse to man].  |  Blin-Wakkach, C., et al. 2004. Med Sci (Paris). 20: 61-7. PMID: 14770365
4. Identification of a novel mutation in the coding region of the grey-lethal gene OSTM1 in human malignant infantile osteopetrosis.  |  Ramírez, A., et al. 2004. Hum Mutat. 23: 471-6. PMID: 15108279
5. ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function.  |  Lange, PF., et al. 2006. Nature. 440: 220-3. PMID: 16525474
6. Mutations in OSTM1 (grey lethal) define a particularly severe form of autosomal recessive osteopetrosis with neural involvement.  |  Pangrazio, A., et al. 2006. J Bone Miner Res. 21: 1098-105. PMID: 16813530
7. Clinical and cellular manifestations of OSTM1-related infantile osteopetrosis.  |  Maranda, B., et al. 2008. J Bone Miner Res. 23: 296-300. PMID: 17922613
8. OSTM1 regulates beta-catenin/Lef1 interaction and is required for Wnt/beta-catenin signaling.  |  Feigin, ME. and Malbon, CC. 2008. Cell Signal. 20: 949-57. PMID: 18296023
9. OSTM1 bone defect reveals an intercellular hematopoietic crosstalk.  |  Pata, M., et al. 2008. J Biol Chem. 283: 30522-30. PMID: 18790735

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OSTM1 Antibody (4H1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-OSTM1 Antibody (4H1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OSTM1 Antibody (4H1) Specifications

Alternate Product Name: OSTM1

Product Clone Name: 4H1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 183-282

Epitope Target: OSTM1

Epitope Species: human

Product Reactivity/Detection: OSTM1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for OSTM1 Antibody (4H1): N/A