OR3A4 Inhibitors
OR3A4 contains inhibitors such as LY294002 and Wortmannin would function by obstructing the PI3K/Akt signaling pathway. If OR3A4 operates within this pathway, these inhibitors would prevent its activation by impeding the upstream kinase PI3K. PD98059 and SB203580 would serve to inhibit the MAPK/ERK and p38 MAPK pathways, respectively. Their function would be to block the phosphorylation events crucial for the signal transduction that might activate or regulate OR3A4. Compounds like U73122 and BAPTA would act by altering intracellular signaling mediators, with U73122 inhibiting the enzyme phospholipase C to reduce second messengers like diacylglycerol and inositol triphosphate, and BAPTA chelating calcium ions, thereby potentially affecting calcium-dependent functions of OR3A4. SP600125 would inhibit the JNK signaling pathway, potentially impacting the transcriptional regulation of OR3A4.
Proteasome inhibitor MG132 would function to prevent the degradation of intracellular proteins, which could lead to the accumulation of negative regulatory proteins that control OR3A4 activity. ZM-447439, an Aurora kinase inhibitor, would disrupt cell cycle progression and could inhibit any cell cycle-related functions of OR3A4. Rapamycin, an mTOR inhibitor, would likely suppress OR3A4 function by halting the mTORC1 pathway, which could influence OR3A4's role in cell growth or metabolism. NF449 would inhibit G-protein signaling, potentially blocking OR3A4 activity if it is G-protein coupled. Lastly, Cyclopamine would impede the Hedgehog signaling pathway, which might regulate OR3A4.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A specific inhibitor of PI3K, which can block the PI3K/Akt signaling pathway. If OR3A4 is part of this pathway, LY294002 can prevent its activation by inhibiting PI3K. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A selective inhibitor of MEK1/2, which can inhibit the MAPK/ERK pathway. If OR3A4 functions downstream of this pathway, PD98059 can suppress its activity by preventing ERK phosphorylation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that can block p38-mediated signaling events. If OR3A4 is activated by p38 MAPK, SB203580 can inhibit its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which can prevent the activation of c-Jun and subsequent transcriptional events. If OR3A4 acts downstream of JNK, SP600125 can inhibit its expression or activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that can prevent the degradation of proteins, potentially increasing the levels of negative regulators of OR3A4, thus indirectly inhibiting its function. | ||||||
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $68.00 $267.00 | 10 | |
A calcium chelator that can reduce intracellular calcium levels. If OR3A4 is calcium-dependent, BAPTA can inhibit its activity by lowering available calcium. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A potent PI3K inhibitor like LY294002, which can block PI3K/Akt signaling. Wortmannin can inhibit OR3A4 activity by preventing PI3K-mediated signaling if OR3A4 is part of this pathway. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
An Aurora kinase inhibitor that can interfere with mitotic progression. If OR3A4 is involved in cell cycle regulation and is modulated by Aurora kinase activity, ZM-447439 can inhibit its function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can suppress the mTORC1 pathway. If OR3A4 is regulated by or interacts with components of the mTORC1 pathway, Rapamycin can inhibit its activity. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $203.00 $469.00 $1509.00 | 1 | |
A potent and selective inhibitor of Gs-alpha subunit of G-proteins. If OR3A4 is G-protein coupled, NF449 can inhibit its signaling by preventing G-protein activation. | ||||||