NVL Activators
NVL Activators as a class encompass a range of compounds that can indirectly influence the expression or activity of NVL. These compounds generally function by modulating stress response pathways, heat shock protein activity, and proteostasis mechanisms within the cell. For example, Hsp90 inhibitors like 17-AAG, geldanamycin, and radicicol can disrupt the function of Hsp90 and thereby potentially upregulate NVL through the cellular heat shock response, which aims to restore protein homeostasis under conditions of stress. This class of compounds does not act on NVL directly but rather induces a broader stress response that may result in increased expression or activity of NVL along with other molecular chaperones.
Additionally, compounds that modulate proteostasis, such as MG132, can lead to an accumulation of misfolded proteins, thereby necessitating increased chaperone activity where NVL could play a role. Antioxidants and polyphenols like coniferyl alcohol, celastrol, withaferin A, EGCG, and curcumin also engage with cellular protective responses, potentially affecting the regulation of proteins involved in stress response, including NVL.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin binds to Hsp90 and inhibits its chaperone activity. Hsp90 is involved in the proper folding and function of many proteins, including those related to the proteasome pathway. NVL is thought to participate in ribosome biogenesis and may also be linked to proteasome function. The inhibition of Hsp90 can cause a cellular stress response that upregulates the proteasome pathway, potentially increasing the activity or stability of NVL as the cell attempts to rescue misfolded proteins. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor. By preventing the degradation of ubiquitinated proteins, MG132 can increase cellular stress, which may lead to a compensatory upregulation of proteins involved in protein folding and degradation pathways, potentially including NVL. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG, another Hsp90 inhibitor, functions similarly to geldanamycin. By hindering Hsp90 activity, it can induce a stress response that enhances the expression of molecular chaperones and components of the proteasome system, possibly leading to increased NVL activity as part of the cellular response to maintain proteostasis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is a protein synthesis inhibitor. By blocking translation, it can lead to the activation of cellular stress pathways, which might include upregulation of NVL, as it is associated with ribosome biogenesis and may be part of a feedback mechanism to restore normal function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and metabolism. Inhibition of mTOR can lead to enhanced autophagy and may increase the cellular demand for ribosome biogenesis, potentially upregulating NVL as a component of this process. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, a specific proteasome inhibitor, can lead to increased cellular stress and may trigger a compensatory increase in proteins associated with protein quality control mechanisms, including NVL. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Puromycin causes premature chain termination during protein synthesis, similar to cycloheximide, leading to stress responses that might include the upregulation of NVL. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase inhibitor that can alter gene expression. By affecting chromatin structure, it may increase the transcription of genes related to the cellular stress response, potentially upregulating NVL. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal is a selective inhibitor of phosphatases that dephosphorylate eIF2α, leading to enhanced eIF2α phosphorylation and an attenuation of global protein synthesis, which can result in increased expression of proteins involved in stress response, potentially including NVL. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can affect glycogen synthase kinase-3 (GSK-3) activity and may influence Wnt signaling pathway components. Although not directly linked to NVL, changes in these pathways can have downstream effects on cellular stress responses and protein homeostasis, possibly impacting NVL activity. | ||||||