NVL Inhibitors
NVL inhibitors primarily focus on hampering processes linked with ribosome biogenesis and related cellular functions. The AAA ATPase NVL is intricately associated with ribosome biogenesis, a vital cellular process where rRNA transcription plays a central role. Compounds like Actinomycin D, CX-5461, and BMH-21 directly target this rRNA transcription process. By binding to DNA or inhibiting RNA polymerase I, these chemicals can disrupt rRNA synthesis, thereby affecting the entire ribosome biogenesis pathway where NVL operates.
Moreover, ribosome biogenesis isn't an isolated process. It ties into broader cellular activities like RNA processing, translation, and even RNA splicing. Compounds like Silvestrol and Rocaglamide affect translation initiation by targeting the eIF4A helicase. Such disruptions in translation might indirectly influence NVL's associated roles in ribosome biogenesis. Furthermore, the spliceosome, essential for RNA splicing, is targeted by Pladienolide B, and E7107. By affecting the spliceosome's function, these chemicals can cause cascading effects on RNA processing, potentially influencing NVL's activity. The convergence of these chemical actions signifies the complexity of cellular processes and the interwoven nature of NVL's role in ribosome biogenesis.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds DNA and inhibits RNA synthesis, affecting ribosomal RNA (rRNA) transcription. This can indirectly affect NVL's role in ribosome biogenesis. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $245.00 | ||
Inhibits RNA polymerase I-driven transcription of rRNA. NVL's involvement in ribosome biogenesis can be affected by disrupted rRNA synthesis. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
Binds to GC-rich rDNA and inhibits RNA polymerase I, affecting rRNA synthesis and potentially NVL's function. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Inhibits RNA synthesis, potentially influencing NVL's associated pathways in ribosome biogenesis. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Incorporated into RNA, disrupting RNA processing and function, which can indirectly influence NVL's role. | ||||||
Rocaglamide C | 189322-67-6 | sc-202793 | 50 µg | $109.00 | ||
Inhibits translation initiation by targeting the eIF4A helicase, affecting ribosome function and potentially NVL's associated processes. | ||||||
Silvestrol | 697235-38-4 | sc-507504 | 1 mg | $920.00 | ||
Inhibits the eIF4A helicase, impacting protein translation, which can influence ribosomal processes and NVL's role. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Targets SF3b complex of the spliceosome, affecting RNA splicing and potentially influencing NVL-associated processes. | ||||||