Actinomycin D CAS: 50-76-0
MF: C62H86N12O16
MW: 1255.42
A potent antibiotic that binds to the GpC steps of DNA.

Actinomycin D (CAS 50-76-0)

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同義語 Oncostatin K; Actinomycin IV
アプリケーション: A potent antibiotic that binds to the GpC steps of DNA
CAS 番号: 50-76-0
Purity: ≥98%
Molecular Weight: 1255.42
Molecular Formula: C62H86N12O16
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria. Actinomycin D can induce apoptosis in several cell lines such as lung and prostate cancer lines, and human blood lymphocytes, among others. This compound is also an RNA polymerase inhibitor. In studies it has been observed that Actinomycin D elevates p53 expression, leading to the increase of PUMAα/β (the p53 upregulated modulator of apoptosis protein; PUMA), and can also induce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced caspase-dependent and -independent apoptosis.


参考文献

1. Bailey, S.A., et al. 1993. Biochemistry. 32: 5881-5887. PMID: 8504108
2. Verhaegen, S., et al. 1995. Biochem. Pharmacol. 50: 1021-1029. PMID: 7575657
3. Kalousek, I., et al. 2007. Anticancer Drugs. 18: 763-772. PMID: 17581298
4. Wang, M.J., et al. 2007. Neurosci. Res. 59: 40-46. PMID: 17707539
5. Xu, H. and Krystal, G.W. 2010. Clin Cancer Res. PMID: 20732961

Physical State :
Solid
Derived From :
Streptomyces parvulus
Solubility :
Soluble in DMSO (>20 mg/ml), 100% ethanol (1 mg/ml), methanol, chloroform, acetonitrile (9.80 - 10.20 mg/ml), and 1,2-Propanediol.
保存方法 :
Store at -20° C
Melting Point :
251-253° C
Boiling Point :
1386.05° C at 760 mmHg (Predicted)
Density :
1.43 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
Optical Activity :
α28/D -315°, c = 0.25 in methanol
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
AU1575000
PubChem CID :
2019
Merck Index :
14: 2800
MDL Number :
MFCD00005033
EC Number :
200-063-6
Beilstein Registry :
605235
SMILES :
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C

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Actinomycin D  参考文献

See how others have used Actinomycin D. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 23 total

PMID: # 31222373  Luo, Y. et al. 2019. Cell. Mol. Life Sci.

PMID: # 30870073  Song, H.|Feng, X.|Zhang, H.|Luo, Y.|Huang, J.|Lin, M.|Jin, J.|Ding, X.|Wu, S.|Huang, H.|Yu, T.|Zhang, M.|Hong, H.|Yao, S.|Zhao, Y.|Zhang, Z.| et al. 2019. Autophagy. 15: 1419-1437.

PMID: # 30796352  Yang, F.|Jin, H.|Que, B.|Chao, Y.|Zhang, H.|Ying, X.|Zhou, Z.|Yuan, Z.|Su, J.|Wu, B.|Zhang, W.|Qi, D.|Chen, D.|Min, W.|Lin, S.|Ji, W.| et al. 2019. Oncogene. 38: 4755-4772.

PMID: # 30639474  Liu, Y.|Wei, W.|Hong, C.|Wang, Y.|Sun, X.|Ma, J.|Zheng, F.| et al. 2019. Mol. Immunol. 107: 10-20.

PMID: # 30821592  Peng, M.|Wang, J.|Tian, Z.|Zhang, D.|Jin, H.|Liu, C.|Xu, J.|Li, J.|Hua, X.|Xu, J.|Huang, C.|Huang, C.| et al. 2019. Autophagy.

PMID: # 31119302  Liu, Y.|Wei, W.|Wang, Y.|Wan, C.|Bai, Y.|Sun, X.|Ma, J.|Zheng, F.| et al. 2019. Inflamm. Res. 68: 597-611.

PMID: # 30873168  Figliuolo da Paz, V.|Jamwal, DR.|Gurney, M.|Midura-Kiela, M.|Harrison, CA.|Cox, C.|Wilson, JM.|Ghishan, FK.|Kiela, PR.| et al. 2019. Front Immunol. 10: 304.

PMID: # 30602711  Weiss, J.| et al. 2018. Molecules. 24:

PMID: # 30414569  Shu, Y.|Wu, K.|Zeng, Z.|Huang, S.|Ji, X.|Yuan, C.|Zhang, L.|Liu, W.|Huang, B.|Feng, Y.|Zhang, B.|Dai, Z.|Shen, Y.|Luo, W.|Wang, X.|Liu, B.|Lei, Y.|Ye, Z.|Zhao, L.|Cao, D.|Yang, L.|Chen, X.|Luu, HH.|Reid, RR.|Wolf, JM.|Lee, MJ.|He, TC.| et al. 2018. Mol Ther Nucleic Acids. 13: 556-567.

PMID: # 29684377  Tocchetti, GN. et al. 2018. Biochem. Pharmacol. 154: 118-126.

Citations 1 to 10 of 23 total
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