Actinomycin D CAS: 50-76-0
MF: C62H86N12O16
MW: 1255.42
A potent antibiotic that binds to the GpC steps of DNA.

Actinomycin D (CAS 50-76-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 197ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
同義語 Oncostatin K; Actinomycin IV
アプリケーション: A potent antibiotic that binds to the GpC steps of DNA
CAS 番号: 50-76-0
Purity: ≥98%
Molecular Weight: 1255.42
Molecular Formula: C62H86N12O16
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
この製品のレビューを提出し、15 CruzCreditsを受け取ります

Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria. Actinomycin D can induce apoptosis in several cell lines such as lung and prostate cancer lines, and human blood lymphocytes, among others. This compound is also an RNA polymerase inhibitor. In studies it has been observed that Actinomycin D elevates p53 expression, leading to the increase of PUMAα/β (the p53 upregulated modulator of apoptosis protein; PUMA), and can also induce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced caspase-dependent and -independent apoptosis.


1. Bailey, S.A., et al. 1993. Biochemistry. 32: 5881-5887. PMID: 8504108
2. Verhaegen, S., et al. 1995. Biochem. Pharmacol. 50: 1021-1029. PMID: 7575657
3. Kalousek, I., et al. 2007. Anticancer Drugs. 18: 763-772. PMID: 17581298
4. Wang, M.J., et al. 2007. Neurosci. Res. 59: 40-46. PMID: 17707539
5. Xu, H. and Krystal, G.W. 2010. Clin Cancer Res. PMID: 20732961

Physical State :
Derived From :
Streptomyces parvulus
Solubility :
Soluble in DMSO (>20 mg/ml), 100% ethanol (1 mg/ml), methanol, chloroform, acetonitrile (9.80 - 10.20 mg/ml), and 1,2-Propanediol.
保存方法 :
Store at -20° C
Melting Point :
251-253° C
Boiling Point :
1386.05° C at 760 mmHg (Predicted)
Density :
1.43 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
Optical Activity :
α28/D -315°, c = 0.25 in methanol
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
PubChem CID :
Merck Index :
14: 2800
MDL Number :
EC Number :
Beilstein Registry :

Download SDS (MSDS)


Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Actinomycin D  参考文献

See how others have used Actinomycin D. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 23 total

PMID: # 31222373  Luo, Y. et al. 2019. Cell. Mol. Life Sci.

PMID: # 30870073  Song, H.|Feng, X.|Zhang, H.|Luo, Y.|Huang, J.|Lin, M.|Jin, J.|Ding, X.|Wu, S.|Huang, H.|Yu, T.|Zhang, M.|Hong, H.|Yao, S.|Zhao, Y.|Zhang, Z.| et al. 2019. Autophagy. 15: 1419-1437.

PMID: # 30796352  Yang, F.|Jin, H.|Que, B.|Chao, Y.|Zhang, H.|Ying, X.|Zhou, Z.|Yuan, Z.|Su, J.|Wu, B.|Zhang, W.|Qi, D.|Chen, D.|Min, W.|Lin, S.|Ji, W.| et al. 2019. Oncogene. 38: 4755-4772.

PMID: # 30639474  Liu, Y.|Wei, W.|Hong, C.|Wang, Y.|Sun, X.|Ma, J.|Zheng, F.| et al. 2019. Mol. Immunol. 107: 10-20.

PMID: # 30821592  Peng, M.|Wang, J.|Tian, Z.|Zhang, D.|Jin, H.|Liu, C.|Xu, J.|Li, J.|Hua, X.|Xu, J.|Huang, C.|Huang, C.| et al. 2019. Autophagy.

PMID: # 31119302  Liu, Y.|Wei, W.|Wang, Y.|Wan, C.|Bai, Y.|Sun, X.|Ma, J.|Zheng, F.| et al. 2019. Inflamm. Res. 68: 597-611.

PMID: # 30873168  Figliuolo da Paz, V.|Jamwal, DR.|Gurney, M.|Midura-Kiela, M.|Harrison, CA.|Cox, C.|Wilson, JM.|Ghishan, FK.|Kiela, PR.| et al. 2019. Front Immunol. 10: 304.

PMID: # 30602711  Weiss, J.| et al. 2018. Molecules. 24:

PMID: # 30414569  Shu, Y.|Wu, K.|Zeng, Z.|Huang, S.|Ji, X.|Yuan, C.|Zhang, L.|Liu, W.|Huang, B.|Feng, Y.|Zhang, B.|Dai, Z.|Shen, Y.|Luo, W.|Wang, X.|Liu, B.|Lei, Y.|Ye, Z.|Zhao, L.|Cao, D.|Yang, L.|Chen, X.|Luu, HH.|Reid, RR.|Wolf, JM.|Lee, MJ.|He, TC.| et al. 2018. Mol Ther Nucleic Acids. 13: 556-567.

PMID: # 29684377  Tocchetti, GN. et al. 2018. Biochem. Pharmacol. 154: 118-126.

Citations 1 to 10 of 23 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 113ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

サンタクルーズバイオテクノロジーは生物医学研究市場向けの製品の開発における世界的リーダです。 下記フリー ダイヤルにお電話ください: 1-800-457-3801。Copyright © 2007-2020 Santa Cruz Biotechnology, Inc.全著作権所有。"Santa Cruz Biotechnology"、 及びSanta Cruz Biotechnology, Inc. ロゴ、 "Santa Cruz Animal Health"、 "San Juan Ranch"、 "Supplement of Champions"、 San Juan Ranch ロゴ、 "Ultracruz"、 "Chemcruz"、 "Immunocruz"、 "Exactacruz"、 と "EZ Touch"はサンタクルーズバイオテクノロジーの登録商標です。 商標はそれぞれの所有者に帰属します。