NVL Antibody (G-10): sc-393047
- NVL Antibody (G-10) is a mouse monoclonal IgG1 κ NVL antibody provided at 200 µg/ml
- raised against amino acids 405-482 mapping within an internal region of NVL of human origin
- NVL Antibody (G-10) is recommended for detection of NVL of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-NVL Antibody (G-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of NVL (G-10): sc-393047.
- m-IgG1 BP-HRP is the preferred secondary detection reagent for NVL Antibody (G-10) for WB applications. This reagent is now offered in a bundle with NVL Antibody (G-10) (see ordering information below).
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SEE ALSO...
NVL Antibody (G-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects NVL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NVL (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NVL protein, also known as nuclear valosin-containing protein-like, is a crucial member of the AAA ATPase family, consisting of 856 amino acids and playing a significant role in ATP-dependent nuclear processes and ribosome synthesis. NVL is predominantly localized in the nucleus, which is vital for regulating essential cellular activities, including cell cycle and membrane functions. Nuclear presence allows for efficient interaction with various substrates involved in these processes, ensuring proper cellular function and response to stress. Additionally, NVL exists in three alternatively spliced isoforms, which may contribute to diverse functional roles. NVL protein is widely expressed, with highest levels found in pancreas, retina, heart, skeletal muscle, and placenta, underscoring importance in various physiological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NVL Antibody (G-10) References:
- Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1. | Zhang, SH., et al. 1999. J Biol Chem. 274: 17806-12. PMID: 10364224
- Functional proteomic analysis of human nucleolus. | Scherl, A., et al. 2002. Mol Biol Cell. 13: 4100-9. PMID: 12429849
- VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation. | Egerton, M., et al. 1992. EMBO J. 11: 3533-40. PMID: 1382975
- NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence. | Nagahama, M., et al. 2004. Mol Biol Cell. 15: 5712-23. PMID: 15469983
- [National disease management guidelines (NVL) for chronic CAD: What is new, what is particularly important?]. | Werdan, K. 2016. Herz. 41: 537-60. PMID: 27586137
- NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations. | Drilon, A., et al. 2023. Cancer Discov. 13: 598-615. PMID: 36511802
- Guidelines' recommendations for the treatment-resistant depression: A systematic review of their quality. | Gabriel, FC., et al. 2023. PLoS One. 18: e0281501. PMID: 36745622
- Strategies to overcome resistance to ALK inhibitors in non-small cell lung cancer: a narrative review. | Desai, A. and Lovly, CM. 2023. Transl Lung Cancer Res. 12: 615-628. PMID: 37057106
- NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations. | Lin, JJ., et al. 2024. Cancer Discov. 14: 2367-2386. PMID: 39269178
- NVL: a new member of the AAA family of ATPases localized to the nucleus. | Germain-Lee, EL., et al. 1997. Genomics. 44: 22-34. PMID: 9286697
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NVL Antibody (G-10) | sc-393047 | 200 µg/ml | $316.00 | |||
NVL Antibody (G-10): m-IgG1 BP-HRP Bundle | sc-531753 | 200 µg Ab; 20 µg BP | $354.00 | |||
NVL Antibody (G-10) AC | sc-393047 AC | 500 µg/ml, 25% agarose | $416.00 | |||
NVL Antibody (G-10) HRP | sc-393047 HRP | 200 µg/ml | $316.00 | |||
NVL Antibody (G-10) FITC | sc-393047 FITC | 200 µg/ml | $330.00 | |||
NVL Antibody (G-10) PE | sc-393047 PE | 200 µg/ml | $343.00 | |||
NVL Antibody (G-10) Alexa Fluor® 488 | sc-393047 AF488 | 200 µg/ml | $357.00 | |||
NVL Antibody (G-10) Alexa Fluor® 546 | sc-393047 AF546 | 200 µg/ml | $357.00 | |||
NVL Antibody (G-10) Alexa Fluor® 594 | sc-393047 AF594 | 200 µg/ml | $357.00 | |||
NVL Antibody (G-10) Alexa Fluor® 647 | sc-393047 AF647 | 200 µg/ml | $357.00 | |||
NVL Antibody (G-10) Alexa Fluor® 680 | sc-393047 AF680 | 200 µg/ml | $357.00 | |||
NVL Antibody (G-10) Alexa Fluor® 790 | sc-393047 AF790 | 200 µg/ml | $357.00 |