NTN Inhibitors
Chemical inhibitors of Neurturin (NTN) can function through various pathways to achieve inhibition of this neurotrophic factor's signaling. Staurosporine serves as a broad-spectrum kinase inhibitor, which can block the kinase-dependent signaling cascades essential for NTN-mediated activities. By inhibiting multiple kinases, Staurosporine can disrupt downstream NTN signaling, thus inhibiting the NTN's role in promoting neuronal differentiation and survival. Similarly, K252a specifically inhibits Trk receptors, which are crucial for NTN signal transduction. The inhibition of Trk receptors by K252a prevents the propagation of NTN signaling, which is essential for its biological effects. CEP-701, another Trk receptor tyrosine kinase inhibitor, operates on the same principle, leading to the functional inhibition of NTN by blocking the receptors that NTN binds to initiate its signal cascade.
Further down the signaling pathways, PD 98059 and U0126 selectively inhibit MEK/ERK pathway enzymes, a critical downstream pathway of NTN signaling. These inhibitors prevent the phosphorylation and activation of ERK, a key mediator of NTN's actions in neuronal cells. LY294002 and Wortmannin are both phosphatidylinositol 3-kinase (PI3K) inhibitors, and by blocking PI3K, they impair the activation of the AKT pathway, which is essential for NTN's survival and growth-promoting effects in neurons. SB203580 and SP600125 target the p38 MAPK and JNK pathways, respectively, which are other MAPK signaling pathways NTN can activate. Inhibition of these kinases by SB203580 and SP600125 can impede the cellular responses to NTN, leading to the protein's functional inhibition. PP2 is an inhibitor of the Src family kinases, which are involved in NTN signaling; its inhibition can therefore suppress the functional activity of NTN. AG490 targets the JAK2 kinase, disrupting the JAK-STAT signaling that NTN may utilize. Last, Go6976 inhibits Protein Kinase C (PKC), which is known to participate in NTN signaling, leading to the disruption of NTN-mediated pathways and inhibition of NTN's influence on neuronal functions.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, and it can inhibit the downstream signaling of NTN by inhibiting kinases that are responsible for NTN signal transduction, thus functionally inhibiting NTN's role in neuronal differentiation and survival. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $126.00 $210.00 $488.00 | 19 | |
K252a is a kinase inhibitor that can inhibit Trk receptors, which are known to bind neurotrophins including NTN. By inhibiting Trk receptor signaling, K252a can functionally inhibit the signaling cascades initiated by NTN, leading to inhibition of NTN's biological effects. | ||||||
Lestaurtinib | 111358-88-4 | sc-218657 sc-218657A sc-218657B | 1 mg 5 mg 10 mg | $270.00 $320.00 $600.00 | 3 | |
CEP-701 is an inhibitor of Trk receptor tyrosine kinases. Since NTN signals through Trk receptors, CEP-701 can inhibit NTN-induced signaling pathways, leading to functional inhibition of NTN. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of the MEK/ERK pathway, which is a downstream pathway of NTN signaling. By inhibiting MEK, PD 98059 can disrupt the ERK pathway activation that is induced by NTN, thus functionally inhibiting NTN's effects on neuronal cells. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is a part of NTN signaling pathway, and its inhibition by LY294002 can prevent the activation of downstream targets such as AKT, resulting in functional inhibition of NTN-mediated survival and growth pathways in neurons. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, enzymes that are involved in the MAPK/ERK pathway, a downstream signaling pathway of NTN. Inhibition of MEK1/2 by U0126 can thus inhibit the functional effects of NTN on neuronal differentiation and survival. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, which can be involved in the signaling pathways activated by NTN. Inhibition of p38 MAPK by SB203580 can impair the cellular responses to NTN, leading to functional inhibition of NTN's role in neuronal cells. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK signaling pathways that can be activated by NTN. By inhibiting JNK, SP600125 can disrupt NTN signaling, leading to functional inhibition of NTN's effects in neurons. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family kinases, which can be activated by NTN binding to its receptors. Src kinases are involved in various signaling pathways including those activated by NTN. Inhibition by PP2 can therefore inhibit the functional effects of NTN. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor, like LY294002, and its inhibition of PI3K can block the activation of downstream signaling pathways of NTN, resulting in functional inhibition of NTN's biological activities. | ||||||