NTN Antibody (D-10): sc-393626
- NTN Antibody (D-10) is a mouse monoclonal IgG2a κ NTN antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 171-197 at the C-terminus of NTN of human origin
- NTN Antibody (D-10) is recommended for detection of NTN of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- Anti-NTN Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for NTN Antibody (D-10) for WB applications. These reagents are now offered in bundles with NTN Antibody (D-10) (see ordering information below).
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NTN Antibody (D-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects NTN protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NTN (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neurturin (NTN) plays a crucial role in neuronal health as a member of the glial cell line-derived neurotrophic factor (GDNF) family, which is essential for the survival and maintenance of both central and peripheral neurons. NTN exerts effects by binding to specific receptors, namely GDNFRa and RETL2, which are linked to the cell membrane via glycosyl-phosphoinositol. These receptors lack transmembrane domains, and activation leads to the stimulation of tyrosine kinase Ret, which is pivotal for downstream signaling pathways. NTN′s ability to activate MAP kinase and phosphoinositide 3-kinase pathways highlights a significant role in promoting neuronal survival and influencing the development of various neuronal populations. Anti-NTN antibody (D-10) in multiple formats serves as a versatile tool for researchers studying the intricate mechanisms of neurotrophic factors and their impact on neuronal health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NTN Antibody (D-10) References:
- GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. | Lin, LF., et al. 1993. Science. 260: 1130-2. PMID: 8493557
- Neurturin, a relative of glial-cell-line-derived neurotrophic factor. | Kotzbauer, PT., et al. 1996. Nature. 384: 467-70. PMID: 8945474
- Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. | Sanicola, M., et al. 1997. Proc Natl Acad Sci U S A. 94: 6238-43. PMID: 9177201
- TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. | Baloh, RH., et al. 1997. Neuron. 18: 793-802. PMID: 9182803
- Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. | Creedon, DJ., et al. 1997. Proc Natl Acad Sci U S A. 94: 7018-23. PMID: 9192684
- Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs. | Widenfalk, J., et al. 1997. J Neurosci. 17: 8506-19. PMID: 9334423
- GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. | Jing, S., et al. 1997. J Biol Chem. 272: 33111-7. PMID: 9407096
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NTN Antibody (D-10) | sc-393626 | 200 µg/ml | $316.00 | |||
NTN Antibody (D-10): m-IgG Fc BP-HRP Bundle | sc-526262 | 200 µg Ab; 10 µg BP | $354.00 | |||
NTN Antibody (D-10): m-IgG2a BP-HRP Bundle | sc-546545 | 200 µg Ab; 10 µg BP | $354.00 | |||
NTN Antibody (D-10) AC | sc-393626 AC | 500 µg/ml, 25% agarose | $416.00 | |||
NTN Antibody (D-10) HRP | sc-393626 HRP | 200 µg/ml | $316.00 | |||
NTN Antibody (D-10) FITC | sc-393626 FITC | 200 µg/ml | $330.00 | |||
NTN Antibody (D-10) PE | sc-393626 PE | 200 µg/ml | $343.00 | |||
NTN Antibody (D-10) Alexa Fluor® 488 | sc-393626 AF488 | 200 µg/ml | $357.00 | |||
NTN Antibody (D-10) Alexa Fluor® 546 | sc-393626 AF546 | 200 µg/ml | $357.00 | |||
NTN Antibody (D-10) Alexa Fluor® 594 | sc-393626 AF594 | 200 µg/ml | $357.00 | |||
NTN Antibody (D-10) Alexa Fluor® 647 | sc-393626 AF647 | 200 µg/ml | $357.00 | |||
NTN Antibody (D-10) Alexa Fluor® 680 | sc-393626 AF680 | 200 µg/ml | $357.00 | |||
NTN Antibody (D-10) Alexa Fluor® 790 | sc-393626 AF790 | 200 µg/ml | $357.00 | |||
NTN (D-10) Neutralizing Peptide | sc-393626 P | 100 µg/0.5 ml | $68.00 |