Nlrp12 Inhibitors
Nlrp12 inhibitors are chemicals that modulate the activity of the Nlrp12 protein, a pivotal factor in inflammation and immunity, largely by regulating the NF-κB signaling pathway. These inhibitors, such as Bay 11-7082, Parthenolide, and PDTC, primarily target NF-κB activation. By controlling this pathway, these inhibitors can indirectly influence the actions governed by Nlrp12, given that this protein is an essential modulator of the same signaling processes.
The variety among these chemicals is expansive. Some, like MG-132, act as proteasome inhibitors, halting NF-κB activation and thus affecting Nlrp12 functions. Others, including IKK-16, IMD-0354, and BMS-345541, specifically inhibit IKK, a kinase complex responsible for activating NF-κB. Compounds such as JSH-23 disrupt NF-κB nuclear translocation, a critical step in the NF-κB activation process.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibitor of NF-κB activation, indirectly influencing Nlrp12 pathway. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Suppresses NF-κB activation, thereby can influence Nlrp12-modulated pathways. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
Inhibitor of NF-κB activation which can indirectly modulate Nlrp12 pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that prevents NF-κB activation, thereby affecting Nlrp12. | ||||||
QNZ | 545380-34-5 | sc-200675 | 1 mg | $117.00 | 12 | |
Inhibits NF-κB activation and could influence Nlrp12 pathways. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $133.00 | 12 | |
IKK inhibitor, prevents NF-κB activation which indirectly modulates Nlrp12 activity. | ||||||
IMD 0354 | 978-62-1 | sc-203084 | 5 mg | $199.00 | 3 | |
Inhibits IKKβ, leading to suppression of NF-κB, influencing Nlrp12-modulated pathways. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $312.00 | 1 | |
IKK inhibitor that suppresses NF-κB activation, indirectly affecting Nlrp12. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
Inhibits NF-κB nuclear translocation, indirectly influencing Nlrp12 activity. | ||||||
Wedelolactone | 524-12-9 | sc-200648 sc-200648A | 1 mg 5 mg | $110.00 $337.00 | 8 | |
IKK inhibitor and thus prevents NF-κB activation, affecting Nlrp12 indirectly. | ||||||