NK homeobox (NKX) Inhibitors
The NKX family, part of the NK homeobox gene group, encompasses a set of transcription factors characterized by a highly conserved homeodomain, a DNA-binding motif enabling these proteins to regulate gene expression. Members of this family, such as NKX2-1, NKX2-5, and NKX3-1, are crucial in embryonic development and are involved in the formation and differentiation of various tissues, including the heart, lungs, thyroid, and prostate. NKX proteins function by binding to specific DNA sequences in the regulatory regions of target genes, modulating their transcription and thereby influencing developmental processes and tissue homeostasis. They are key players in cell lineage specification and organogenesis, with each member typically associated with the development of specific organs or tissue types. Dysregulation of NKX family genes has been implicated in a range of developmental disorders and diseases, including congenital heart defects, respiratory dysfunction, and certain cancers. Additionally, NKX proteins are involved in signaling pathways that maintain tissue-specific stem cells, further underscoring their role in both development and tissue regeneration.
Targeting NKX (NK homeobox) family genes with small molecules provides a powerful approach to dissecting their roles in developmental biology and disease pathogenesis. Inhibition or disruption of NKX proteins can reveal their specific functions in tissue development and differentiation, as these transcription factors are key regulators of gene expression in various organ systems. By modulating NKX activity, researchers can study the effects on cell lineage specification and organogenesis, providing insights into developmental processes and abnormalities. This approach is particularly valuable in understanding congenital disorders where NKX gene mutations are implicated, such as heart and lung malformations. Additionally, targeting NKX proteins can elucidate their role in adult tissues, especially in the context of cancer, where their dysregulation might contribute to tumor progression and metastasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
IWP-2 inhibits Wnt signaling by blocking the Wnt/β-catenin pathway. NKX (NK homeobox) is involved in pancreatic development influenced by Wnt signaling, and inhibition of this pathway by IWP-2 can indirectly inhibit NKX (NK homeobox). | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
LDN-193189 inhibits BMP signaling by targeting BMP type I receptors. As NKX (NK homeobox) is influenced by BMP signaling during neural development, inhibition of BMP by LDN-193189 can indirectly inhibit NKX (NK homeobox). | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $64.00 $131.00 $204.00 | 6 | |
GANT-61 inhibits Hedgehog (Hh) signaling by blocking the GLI transcription factors. NKX (NK homeobox) is part of the neural tube patterning influenced by Hh signaling, and GANT-61 can indirectly inhibit NKX (NK homeobox) by interfering with Hh pathway activity. | ||||||
SIS3 hydrochloride | 521984-48-5 | sc-253565 | 5 mg | $334.00 | 2 | |
SIS3 inhibits TGF-β/Smad3 signaling by blocking Smad3 phosphorylation. NKX (NK homeobox) is implicated in pancreatic development influenced by TGF-β signaling, and SIS3 can indirectly inhibit NKX (NK homeobox) by modulating the TGF-β/Smad3 pathway. | ||||||
PARP Inhibitor XI, DR2313 | 284028-90-6 | sc-202756 | 5 mg | $63.00 | ||
XAV939 inhibits Wnt signaling by promoting the degradation of β-catenin. As NKX (NK homeobox) is involved in pancreatic development influenced by Wnt signaling, XAV939 can indirectly inhibit NKX (NK homeobox) by reducing β-catenin levels and Wnt pathway activity. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $213.00 $318.00 $632.00 $1047.00 | 2 | |
DMH1 inhibits BMP signaling by targeting BMP type I receptors. The inhibition of BMP by DMH1 can indirectly inhibit NKX (NK homeobox), as NKX (NK homeobox) is implicated in neural development influenced by BMP signaling. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine inhibits Hedgehog (Hh) signaling by blocking Smoothened (SMO). NKX (NK homeobox) is part of neural tube patterning influenced by Hh signaling, and Cyclopamine can indirectly inhibit NKX (NK homeobox) by disrupting Hh pathway activity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 inhibits TGF-β/Activin/Nodal signaling by blocking the type I receptors. NKX (NK homeobox) is implicated in pancreatic development influenced by TGF-β signaling, and SB431542 can indirectly inhibit NKX (NK homeobox) by interfering with the TGF-β/Activin/Nodal pathway. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1-endo inhibits Wnt signaling by stabilizing Axin. NKX (NK homeobox) is involved in pancreatic development influenced by Wnt signaling, and IWR-1-endo can indirectly inhibit NKX (NK homeobox) by promoting the degradation of β-catenin and modulating Wnt pathway activity. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $186.00 $751.00 | 28 | |
Dorsomorphin inhibits BMP signaling by targeting BMP type I receptors. The inhibition of BMP by Dorsomorphin can indirectly inhibit NKX (NK homeobox), as NKX (NK homeobox) is implicated in neural development influenced by BMP signaling. | ||||||