Molecular structure of PARP Inhibitor XI, DR2313, CAS Number: 284028-90-6
PARP Inhibitor XI, DR2313 (CAS 284028-90-6)
Application:
PARP Inhibitor XI, DR2313 is a competitive and water soluble PARP inhibitor
CAS Number:
284028-90-6
Purity:
≥98%
Molecular Weight:
182.2
Molecular Formula:
C8H10N2OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PARP Inhibitor XI, DR2313 is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor. PARP (Poly(ADP-ribose) polymerase) function by triggering DNA repair mechanisms and activating apoptosis in damaged cells. Studies show that DR2313 competes with NAD+ but does not display selectivity among PARP-1 and PARP-2. In addition, in vitro studies of cerebral ischemia exhibiting an overactivation of PARP show that ischemic damage can be reduced by introducing DR2313.
PARP Inhibitor XI, DR2313 (CAS 284028-90-6) References
- A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. | Nakajima, H., et al. 2005. J Pharmacol Exp Ther. 312: 472-81. PMID: 15466246
- Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. | Lehtiö, L., et al. 2009. J Med Chem. 52: 3108-11. PMID: 19354255
- Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage. | Tang, JB., et al. 2010. Mol Cancer Res. 8: 67-79. PMID: 20068071
- Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia. | Xu, Z., et al. 2010. Am J Physiol Regul Integr Comp Physiol. 299: R215-21. PMID: 20427721
- Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death. | Blenn, C., et al. 2011. Cell Mol Life Sci. 68: 1455-66. PMID: 20878536
- Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. | Ma, W., et al. 2012. Proc Natl Acad Sci U S A. 109: 6590-5. PMID: 22493268
- A high content clonogenic survival drug screen identifies mek inhibitors as potent radiation sensitizers for KRAS mutant non-small-cell lung cancer. | Lin, SH., et al. 2014. J Thorac Oncol. 9: 965-973. PMID: 24922006
- Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury. | Han, X., et al. 2016. J Cereb Blood Flow Metab. 36: 1059-74. PMID: 26661165
- Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis. | Zhang, J., et al. 2017. J Cereb Blood Flow Metab. 37: 1982-1993. PMID: 27381826
- Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells. | Okuda, A., et al. 2017. BMC Neurosci. 18: 14. PMID: 28095779
- Targeting Parthanatos in Ischemic Stroke. | Koehler, RC., et al. 2021. Front Neurol. 12: 662034. PMID: 34025565
- The Identification of a Novel Calcium-Dependent Link Between NAD+ and Glucose Deprivation-Induced Increases in Protein O-GlcNAcylation and ER Stress. | Zou, L., et al. 2021. Front Mol Biosci. 8: 780865. PMID: 34950703
- Molecular Mechanisms of Parthanatos and Its Role in Diverse Diseases. | Huang, P., et al. 2022. Int J Mol Sci. 23: PMID: 35806303
Inhibitor of:
NK homeobox (NKX), PARP-1, PARP-2, and V1RG12.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PARP Inhibitor XI, DR2313, 5 mg | sc-202756 | 5 mg | $63.00 |