SIS3 hydrochloride (CAS 521984-48-5)
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SIS3 hydrochloride is a specific inhibitor of Smad3 phosphorylation via inhibiting the effects of TGF-beta1. Studies conducted on scleroderma fibroblasts indicate that SIS3 hydrochloride suppresses type I collagen up-regulation. In addition, SIS3 hydrochloride inhibits Smad-responsive p3TP promoter constructs activation. These studies suggest that SIS3 hydrochloride reduces DNA binding of Smad3 and that pretreatment with SIS3 hydrochloride decreases DNA binding by 50%. SIS3 hydrochloride also interferes with the interaction between contransfected Smad3 and Smad4. Furthermore, SIS3 hydrochloride reestablishes myofibroblast differentiation of scleroderma fibroblasts via reducing expression of alpha-SMA in these fibroblasts.
SIS3 hydrochloride (CAS 521984-48-5) References
- Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. | Jinnin, M., et al. 2006. Mol Pharmacol. 69: 597-607. PMID: 16288083
- NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGFβ. | Vidro-Kotchan, E., et al. 2011. Curr Eye Res. 36: 370-8. PMID: 21309688
- Chitosan inhibits fibroblasts growth in Achilles tendon via TGF-β1/Smad3 pathway by miR-29b. | Chen, Q., et al. 2014. Int J Clin Exp Pathol. 7: 8462-70. PMID: 25674210
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SIS3 hydrochloride, 5 mg | sc-253565 | 5 mg | $334.00 |